Results 21 to 30 of about 1,878 (213)
Catastrophic Importance of Catastrophic Forgetting
CoRR, 2018 This paper describes some of the possibilities of artificial neural networks that open up after solving the problem of catastrophic forgetting. A simple model and reinforcement learning applications of existing methods are also proposed.
openaire +3 more sources
Basic and Clinical Neuroscience, 2020 Introduction: Cognitive emotion regulation is suggested to contribute to Illness Anxiety Disorder (IAD). Reappraisal and suppression are essential ER strategies with controversial data about their roles in IAD.
Mina Elhamiasl +3 more
doaj
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Pain Research and Management, 2017 Pain catastrophizing, a pattern of negative cognitive-emotional responses to actual or anticipated pain, maintains chronic pain and undermines response to treatments.
Chloe J. Taub +4 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
The Temporal Relationship between Catastrophizing and Chronic Pain
Canadian Journal of Pain, 2019 Introduction/Aim: Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic pelvic pain syndrome characterized by persistent pain localized to the bladder and urologic symptoms of urgency, frequency, and dysuria (Nickel et al., 2009).
Abi Muere +7 more
doaj +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Pain catastrophizing predicts verbal expression among children with chronic pain and their mothers
Health Psychology Open, 2016 This study examined intra- and inter-personal associations between pain catastrophizing and verbal expression in 70 children with recurrent abdominal pain and their mothers. Participants independently completed the Pain Catastrophizing Scale. Mothers and
Shelby L Langer +5 more
doaj +1 more source
Positive Affect Is Associated With Better Physical Function in Early Rheumatoid Arthritis
Arthritis Care &Research, EarlyView.Objective This study examined the association between positive affect and physical function in individuals with early rheumatoid arthritis (RA). Methods We analyzed baseline data from 129 adults with early RA (persistent joint symptoms for ≤24 months) and active disease enrolled in the Central Pain in RA 2 (CPIRA‐2) study.
Burcu Aydemir +9 more
wiley +1 more source
Advanced Engineering Materials, EarlyView.This study examines how helicoidal architectures with different porosities respond to bending. Adjusting layer angle and spacing in 3D‐printed polymers reveals clear tradeoffs between stiffness, strength, and energy absorption. Experiments and simulations highlight designs that distribute stress effectively, offering pathways for optimizing lightweight
Praveenkumar Subhash Patil +2 more
wiley +1 more source