Results 181 to 190 of about 2,760,134 (248)

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

open access: yesExploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi   +5 more
wiley   +1 more source

Vehicle Fires: Significant Fire Hazard in Transportation Infrastructure

open access: yesFire and Materials, EarlyView.
ABSTRACT Vehicle flammability poses a critical threat to transportation infrastructure, with recent fires in depots, tunnels, and car parks highlighting systemic vulnerabilities. These incidents often result in the total loss of vehicles and buildings, revealing the inadequacy of current fire safety standards for vehicle materials.
Anja Hofmann‐Böllinghaus   +2 more
wiley   +1 more source

Jonah's Sea Catch

open access: yes
Jonah's Sea Catch
core  

Revisiting International Student Mobility Under New Geopolitics: Stratification, Conditionality, and Uncertainty

open access: yesFuture in Educational Research, EarlyView.
ABSTRACT In the 21st century, the governance of international student mobility has undergone a fundamental transformation, driven primarily by securitization, geoeconomic competition, and domestic political pressures that conventional market‐based frameworks such as the push‐pull model and human capital theory cannot adequately explain.
Shibao Guo, Zhongrui Wang
wiley   +1 more source

Engineering an artificial trachea: Quantitative benchmarks and modular strategies for mechanics, epithelialization, and vascular integration

open access: yesFlexMat, EarlyView.
In this work, we first examine the limitations of surgical repair and stenting, including migration, granulation, mucus plugging, and infection. We then translate these failures into engineering constraints involving geometry, mechanics, fixation, degradation, junctional stress, and remodeling.
Yiwei Xu   +6 more
wiley   +1 more source

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