Inhibition of Catechol-O-methyltransferase Does Not Alter Effort-Related Choice Behavior in a Fixed Ratio/Concurrent Chow Task in Male Mice [PDF]
Frontiers in Behavioral Neuroscience, 2020 Effort-related choice (ERC) tasks allow animals to choose between high-value reinforcers that require high effort to obtain and low-value/low-effort reinforcers. Dopaminergic neuromodulation regulates ERC behavior. The enzyme catechol-O-methyltransferase
Adrienne C. DeBrosse +5 more
doaj +2 more sources
Suppressor effect of catechol-O-methyltransferase gene in prostate cancer. [PDF]
PLoS ONE, 2021 Catechol-estrogens can cause genetic mutations and to counteract their oncogenicity, the catechol-O-methyltransferase (COMT) gene is capable of neutralizing these reactive compounds.
Yutaka Hashimoto +11 more
doaj +2 more sources
Investigating the Association between Catechol-O-Methyltransferase Gene Activity and Pain Perception in South African Patients with Different Temporomandibular Disorders Diagnoses [PDF]
BiomedicinesBackground: Temporomandibular disorders (TMD) affect a significant portion of the population, with profound psychological, behavioral, and social repercussions.
Mark Keith Meyer +2 more
doaj +2 more sources
Catechol‐O‐Methyltransferase and Cardiovascular Disease: MESA [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background Genetic variation in catechol‐O‐methyltransferase (COMT), a key enzyme in estrogen and catecholamine metabolism, has plausible physiological links to cardiovascular disease (CVD) and its risk factors.
Kathryn T. Hall +9 more
doaj +2 more sources
Genetic and epigenetic regulation of Catechol-O-methyltransferase in relation to inflammation in chronic fatigue syndrome and Fibromyalgia [PDF]
Journal of Translational Medicine, 2022 Background Catechol-O-methyltransferase (COMT) has been shown to influence clinical pain, descending modulation, and exercise-induced symptom worsening.
Andrea Polli +9 more
doaj +2 more sources
The Catechol O-Methyltransferase Inhibitor Entacapone in the Treatment of Parkinson’s Disease: Personal Reflections on a First-in-Class Drug Development Programme 40 Years On [PDF]
Neurology and TherapyIn the 1980s, Orion Pharma, then a mid-ranking Nordic area pharmaceutical company, established a drug development programme on the inhibition of catechol O-methyltransferase (COMT).
Pekka T. Männistö +4 more
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Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome. [PDF]
PLoS ONE, 2012 Identifying patients who are potential placebo responders has major implications for clinical practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in dopamine catabolism plays a key role in processes associated with the ...
Kathryn T Hall +9 more
doaj +5 more sources
Catechol-O-methyltransferase Inhibitors from Calendula officinalis Leaf [PDF]
Molecules, 2023 Calendula officinalis is commonly known as marigold and its flowers are used in herbal medicines, cosmetics, perfumes, dyes, pharmaceutical preparations, and food products. However, the utility of its leaves has not been studied in depth.
Wataru Kadowaki +4 more
doaj +2 more sources
A catechol-O-methyltransferase genetic variant impacts functional movement in tactical athletes. [PDF]
PLoS ONEFunctional movement is a valuable indicator of physical performance, injury risk, and/or musculoskeletal impairment following injury. However, genetic variation and gene-environment interactions that may affect functional movement are largely unexplored.
Marcus K Taylor +3 more
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Interactions of Acetyl-11-Keto-Beta-Boswellic Acid on Catechol-O-Methyltransferase in the Management of Masticatory Myofascial Pain Syndrome. [PDF]
CureusSuresh R +4 more
europepmc +2 more sources