Results 91 to 100 of about 29,449 (247)

Multi‐Omics Analyses Reveal the Red and Far‐Red Light Combination Enhancing Heterologous Protein and Metabolite Production in Nicotiana benthamiana

Plant, Cell &Environment, EarlyView.
ABSTRACT Transient expression of exogenous protein in Nicotiana benthamiana leaves via agroinfiltration offers a rapid and efficient platform for functional gene discovery and heterologous production of valuable eukaryotic proteins and metabolites. Though light quality is an important factor for plant photomorphogenesis, its impact on the efficiency of
Yating Zhang, Fengjiao Wang, Ran Du, Tao Li, Shaoqun Zhou, Jianbin Yan, Wei Li   +6 more
wiley   +1 more source

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase

Molecular Pain, 2009
Background Catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, has recently been implicated in the modulation of pain.
Conrad Matthew, Wentworth Sean, Qian Li, Nackley Andrea G, Tchivileva Inna E, Diatchenko Luda B   +5 more
doaj   +1 more source

Pathway of human AS3MT arsenic methylation [PDF]

, 2014
A synthetic gene encoding human As(III) S-adenosylmethionine (SAM) methyltransferase (hAS3MT) was expressed, and the purified enzyme was characterized.
Dheeman, Dharmendra S., Packianathan, Charles, Pillai, Jitesh K., Rosen, Barry P.   +3 more
core   +2 more sources

Subcutaneous Levodopa in Parkinson's Disease: A Systematic Review and Meta‐Analysis

European Journal of Neurology, Volume 33, Issue 2, February 2026.
ABSTRACT Background Many Parkinson's disease patients receiving oral levodopa/carbidopa experience a troublesome wearing off effect. Higher doses to mitigate OFF‐time are limited by adverse effects occurring at peak dopamine levels, particularly dyskinesia.
Matthew Burton, Duncan Marsden, Dhruv Harish, Peter Morris, Carl Heneghan, Ailsa Butler, David Nunan   +6 more
wiley   +1 more source

Coupling S-adenosylmethionine-dependent methylation to growth: Design and uses.

PLoS Biology, 2019
We present a selection design that couples S-adenosylmethionine-dependent methylation to growth. We demonstrate its use in improving the enzyme activities of not only N-type and O-type methyltransferases by 2-fold but also an acetyltransferase of another
Hao Luo, Anne Sofie L Hansen, Lei Yang, Konstantin Schneider, Mette Kristensen, Ulla Christensen, Hanne B Christensen, Bin Du, Emre Özdemir, Adam M Feist, Jay D Keasling, Michael K Jensen, Markus J Herrgård, Bernhard O Palsson   +13 more
doaj   +1 more source

Psychosis-inducing effects of cannabis are related to both childhood abuse and COMT genotypes [PDF]

, 2014
OBJECTIVE: To test whether the association between childhood abuse, cannabis use and psychotic experiences (PEs) was moderated by the COMT (catechol-O-methyltransferase) gene.
Alemany, Silvia, Arias, Barbara, Fatjó-Vilas, Mar, Fañanás Saura, Lourdes, Gastó, Cristóbal, Ibáñez, Manuel I, Moya-Higueras, Jorge, Ortet, Generós, Villa Martín, Elena   +8 more
core   +1 more source

Mouse models for preeclampsia: disruption of redox-regulated signaling [PDF]

, 2009
The concept that oxidative stress contributes to the development of human preeclampsia has never been tested in genetically-defined animal models. Homozygous deletion of catechol-Omethyl transferase (Comt-/-) in pregnant mice leads to human preeclampsia ...
A Malassine, AC Epstein, AM Carter, AM Zafari, Anne E Chambers, AP MacKay, BJ Hawkins, C Moser, C Peyssonnaux, CW Redman, D Berg, D Gerald, DS Hoffmann, DS Tannetta, EL Bell, EL Pagé, FX Yi, GL Semenza, H Pelicano, Harpal Randeva, I Thaler, J Golab, J Sugawara, JA Martin, K Kanasaki, L Duley, L Wood, M Geiszt, M Ushio-Fukai, M Wang, N Kanayama, NS Chandel, P Huang, PH Maxwell, R Dworakowski, R Pijnenborg, RD Martin, RK Bruick, RW Redline, S Banerjee, S Lamond, S Melov, S Muzaffar, S Nemoto, SL Adamson, Subhasis Banerjee, T Cramer, T Torbergsen, Y Liu, Y Pan, Y Wang, YA Suh   +51 more
core   +4 more sources

COMT val158met Polymorphism and Spinal Analgesia Efficacy of Laparoscopic Surgery for Colorectal Cancer (a Pilot Study)

Общая реаниматология, 2019
The aim: To assess the effect of COMT G1947A genetic polymorphism (val158met) on the efficacy of spinal analgesia on day 1 after laparoscopic surgery for colorectal cancer.Material and methods.
Alexander L. Potapov, Daria V. Zemskova, Tatiana I. Ivanova, Vera A. Khorokhorina, Peter V. Shegay, Sergey A. Ivanov, Andrey D. Kaprin   +6 more
doaj   +1 more source

Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series) [PDF]

, 2016
The proliferative endothelial and smooth muscle cell phenotype, inflammation, and pulmonary vascular remodeling are prominent features of pulmonary arterial hypertension (PAH).
Awad, Keytam S., de Jesus Perez, Vinicio, MacLean, Margaret, West, James D.   +3 more
core   +1 more source