Results 101 to 110 of about 29,449 (247)

Inhibiting microtubule polymerization with EAPB02303, a prodrug activated by catechol-O-methyl transferase, enhances paclitaxel effect in pancreatic cancer models

Cell Death and Disease
The Imiqualines family is an original group of small heterocyclic compounds, diversely substituted around different scaffolds. Among these compounds, the lead EAPB02303 displays outstanding cytotoxic activity at nanomolar concentrations comparable to ...
Kévin Bigot, Cindy Patinote, Véronique Garambois, Adrien Chouchou, Stéphanie Gayraud-Paniagua, Nadia Vie, Yann Maggipinto, Elias Smyej, Mathilde Robin, Margot Machu, Marine Bruciamacchie, Pierre-Emmanuel Colombo, Corinne Bousquet, Muriel Mathonnet, Ela Levy-Augé, Diego Tosi, Pierre-Antoine Bonnet, Céline Gongora, Carine Deleuze-Masquéfa, Christel Larbouret   +19 more
doaj   +1 more source

Association between the COMT Val158Met Genotype and Alzheimer's Disease in the Han Chinese Population

Dementia and Geriatric Cognitive Disorders Extra, 2014
Background: Alzheimer's disease (AD) is the leading cause of dementia worldwide and is associated with individual, familial and social burdens. Catechol-O-methyltransferase (COMT) may have a prominent role in AD pathophysiology by affecting the ...
Yong Ji, Zhihong Shi, Mengyuan Liu, Shuai Liu, Shuling Liu, Jinhuan Wang   +5 more
doaj   +1 more source

CATECHOLAMINE ASSAY BY RADIOENZYMATIC METHOD - A PROTOCOL

Journal of the Dow University of Health Sciences, 2008
Catecholamines are a group o f compounds identified by the catechol nucleus. The significant catecholaminesfound naturally in the body are epinephrine, nor- epinephrine and dopamine. They are found in varioustissues o f the body like brain, adrenals, GIT,
Nasim Karim, Joshua R. Berlin
doaj  

Heterosis in COMT Val158Met Polymorphism Contributes to Sex-Differences in Children’s Math Anxiety

Frontiers in Psychology, 2019
Math anxiety (MA) is a phobic reaction to math activities, potentially impairing math achievement. Higher frequency of MA in females is explainable by the interaction between genetic and environmental factors.
Annelise Júlio-Costa, Annelise Júlio-Costa, Aline Aparecida Silva Martins, Aline Aparecida Silva Martins, Guilherme Wood, Guilherme Wood, Máira Pedroso de Almeida, Máira Pedroso de Almeida, Marlene de Miranda, Marlene de Miranda, Vitor Geraldi Haase, Vitor Geraldi Haase, Vitor Geraldi Haase, Vitor Geraldi Haase, Vitor Geraldi Haase, Maria Raquel Santos Carvalho, Maria Raquel Santos Carvalho   +16 more
doaj   +1 more source

Assessment of Metabolic Parameters For Autism Spectrum Disorders [PDF]

, 2009
Autism is a brain development disorder that first appears during infancy or childhood, and generally follows a steady course without remission. Impairments result from maturation-related changes in various systems of the brain.
Ghosh, S, Koch, M, Rao, Mr AN, Shobha, G, Suresh Kumar, V   +4 more
core  

Association between the COMT gene and rumination in a Hungarian sample. [PDF]

, 2016
Introduction: Rumination is a multidimensional trait which is a proven risk factor in the vulnerability to depression. The aim to identify the main risk genes for depression in addition to the gene-environment interactions pointed to the importance of
Bagdy, György, Juhász, Gabriella, Pap, Dorottya   +2 more
core  

Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt). [PDF]

, 2017
Transmembrane O-methyltransferase (TOMT / LRTOMT) is responsible for non-syndromic deafness DFNB63. However, the specific defects that lead to hearing loss have not been described.
Erickson, T., Morgan, C.P, Olt, J., Hardy, K., Busch-Nentwich, E.M., Maeda, R., Clemens-Grisham, R., Krey, J.F., Nechiporuk, A.V., Barr-Gillespie, P.G., Marcotti, W., Nicolson, T.   +11 more
core   +2 more sources

Delayed O-methylation of L-DOPA in MB-COMT-deficient mice after oral administration of L-DOPA and carbidopa [PDF]

, 2017
1.Catechol-O-methyltransferase (COMT) is involved in the O-methylation of l-DOPA, dopamine, and other catechols. The enzyme is expressed in two isoforms: soluble (S-COMT), which resides in the cytoplasm, and membrane-bound (MB-COMT), which is anchored to
Aonurm-Helm, Anu, Männistö, Pekka T., Tammimäki, Anne   +2 more
core   +1 more source

Dopamine, time perception, and future time perspective. [PDF]

, 2018
RationaleImpairment in time perception, a critical component of decision-making, represents a risk factor for psychiatric conditions including substance abuse.
Kayser, Andrew S, Mitchell, Jennifer M, Vega, Taylor, Weinstein, Dawn   +3 more
core  

MONOAMINE OXIDASE AND CATECHOL- O-METHYLTRANSFERASE INHIBITORS

Medical Clinics of North America, 1999
Despite advances in the treatment of PD, there remain significant unmet therapeutic needs. This is particularly true at the later stages of the disease when dopaminergic therapy is complicated by motor fluctuations and dyskinesias. Inhibition of dopamine metabolism is a valuable adjunct to exogenous dopaminergic replacement.
A, Siderowf, R, Kurlan
openaire   +2 more sources