Results 211 to 220 of about 29,449 (247)

Catechol-O-methyltransferase in vitiligo

Archives of Dermatological Research, 1994
Catechol-O-methyltransferase (COMT) is involved in the metabolism of neurotransmitters such as epinephrine, norepinephrine and dopamine. For melanocytes, the enzyme is of particular importance in preventing the formation of toxic o-quinones during melanin synthesis. It has been suggested that COMT plays a regulatory role in melanin synthesis.
Le Poole, I. C., van den Wijngaard, R. M., Smit, N. P., Oosting, J., Westerhof, W., Pavel, S.   +5 more
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Human liver catechol-O-methyltransferase pharmacogenetics

Clinical Pharmacology and Therapeutics, 1990
Catechol-O-methyltransferase activity and thermal stability in the human red blood cell are controlled by a common genetic polymorphism. Approximately 25% to 30% of a randomly selected population sample is homozygous for the traits of low catechol-O-methyltransferase activity and thermolabile enzyme in the red blood cell.
B, Boudíková, C, Szumlanski, B, Maidak, R, Weinshilboum   +3 more
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Catechol-O-Methyltransferase and Pain

2010
In animals, different types of COMT inhibitors, irrespective of their brain penetration, are pro-nociceptive in several models of acute and inflammatory pain. Similarly, COMT knock-out mice are more sensitive to nociceptive stimuli, whereas in mice over-expressing a high activity COMT variant nociceptive sensitivity is decreased.
Oleg, Kambur, Pekka T, Männistö
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Crystal structure of catechol O-methyltransferase

Nature, 1994
Catechol O-methyltransferase (COMT, EC 2.1.1.6) is important in the central nervous system because it metabolizes catecholamine neurotransmitters such as dopamine. The enzyme catalyses the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to one hydroxyl group of catechols.
J, Vidgren, L A, Svensson, A, Liljas
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Inhibitors of Catechol-O-Methyltransferase

CNS & Neurological Disorders - Drug Targets, 2012
Since the identification of Catechol-O-Methyltransferase (COMT) by Axelrod in 1957, many inhibitors of this enzyme have been reported. While COMT inhibition may be beneficial in a number of disease states, most of the effort over the years has been directed at boosting L-DOPA concentrations as adjunct treatment for Parkinson's disease.
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Catechol-O-methyltransferase

1993
Publisher Summary This chapter focuses on the biological importance of catechol-O-methyltransferase (COMT) and analytical methods for the measurement of COMT. COMT catalyzes the transfer of a methyl group S -adenosylmethionine to one of the phenolic groups of a catechol in the presence of Mg 2+ .
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Catechol-O-methyltransferase (COMT)

Catechol-O-methyltransferase (COMT) is a magnesium-dependent enzyme responsible for the catalytic O-methylation reaction of endogenous catecholamines and neurotransmitters. It is also involved in the metabolic process of various hormones and drugs incorporating catecholic structures.
Tassone, Giusy, Carradori, Simone, Maramai, Samuele, D'Agostino, Ilaria   +3 more
openaire   +5 more sources

Catechol-O-Methyltransferase Activity in Neuroblastoma Tumour

Nature, 1962
Von Studnitz1, Greenberg and Gardner2, and Voorhess and Gardner3 have reported marked elevations in the urinary excretion of 3-O-methylated metabolites in the urine of patients with neural tumours. It is possible that these urinary products arise mainly from O-methylation of their precursors in the liver.
E H, LABROSSE, M, KARON
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Catechol-O-methyltransferase inhibitors in Parkinson's disease

The Lancet, 1998
2, we observed improvements in the CD4 and CD8 T cell compartments over 6 months consistent with this hypothesis. Our results are also consistent with Li and colleagues who show that adult immune reconstitution requires sustained suppression of HIV-1 replication: child 1 did not show long-lasting improvements in immune markers which coincided with a ...
Xie, T, Ho, SL, Ramsden, D
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A colormetric assay for catechol-O-methyltransferase

Bioorganic & Medicinal Chemistry, 2004
A series of catechol diazo dyes were synthesized and tested as substrates for the enzyme catechol-O-methyltransferase (COMT) with the aim of developing a sensitive HPLC assay method using visible wavelength light detection. A method was developed which allowed for the determination of the two regioisomeric methylated products of the COMT catalyzed ...
Karl, Bailey, Rebecca, Cowling, Eng Wui, Tan, Daniel, Webb   +3 more
openaire   +2 more sources