Results 221 to 230 of about 29,449 (247)
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Catechol-O-Methyltransferase des Menschen
1970A S-adenosylmethionin: catechol-O-methyltransferase, which catalyses the methylation of catecholamines and of 2-hydroxyoestrogens, is localised in the 150000 × g supernatant of human placenta. The enzyme was purified 66fold by ammonium sulphate precipitation and by repeated filtration of the ammonium sulphate precipitate through a Sephadex G-100 column.
Roland Gugler, Heinz Breuer
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Purification and properties of catechol-O-methyltransferase
Biochemical Pharmacology, 1968Abstract A procedure is described for obtaining an improved purification of catechol- O -methyltransferase. The molecular weight of the enzyme is estimated to be 29,000 from its behavior on Sephadex G-100. The presence of multiple bands of activity after polyacrylamide gel electrophoresis is reported.
P J, Anderson, A, D'Ioro
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Catechol-O-methyltransferase in human breast cancers
European Journal of Cancer (1965), 1977Catechol-O-methyltransferase (EC 2-1-1-6) was identified in human breast tissue. The methyltransferase activity of 78 primary carcinomas and 18 benign tumors was determined. Large variations were observed among the examined normal and pathological breast samples.
M, Assicot, G, Contesso, C, Bohuon
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Catechol-O-methyltransferase, Cognition and Alzheimer's Disease
Current Alzheimer Research, 2018Objective: Cognition is a complex trait representing a set of all mental abilities and processes related to knowledge. Although diverse brain regions are involved, most cognitive processes appear to engage cortical regions. The activity of dopaminergic neurons in prefrontal cortex represents a biological substrate underlying cognitive functions ...
Nikolac Perković, Matea +5 more
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Catechol-O-Methyltransferase activity in psychotic children
Journal of Autism and Childhood Schizophrenia, 1976Catechol-O-Methyltransferase (COMT) activity was studied in three groups of institutionalized children: (1) a group of schizophrenic children; (2) a heterogeneous group of chronic psychotic children characterized by severe symptomatology and onset before 5 years of age; (3) a group of acting-out but nonpsychotic children.
H A, Walker, E, Danielson, M, Levitt
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The Chemistry of Catechol-O-Methyltransferase Inhibitors
2010Despite several drawbacks, levodopa (L-dopa) remains the gold standard drug for treatment of the symptoms of Parkinson's disease (PD). L-dopa is a pro-drug of dopamine and is used to elevate striatal levels of the neurotransmitter. One approach to provide a more continuous and sustained delivery of dopamine has targeted one of the principal enzymes ...
David A, Learmonth +2 more
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Catechol-O-Methyltransferase Inhibitors in Parkinson’s Disease
Drugs, 2015Inhibitors of catechol-O-methyltransferase (COMT) are commonly used as an adjunct to levodopa in patients with Parkinson's disease (PD) for the amelioration of wearing-off symptoms. This narrative review aims to discuss the role of COMT inhibitors on peripheral levodopa metabolism and continuous brain delivery of levodopa, and to describe their ...
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