Results 41 to 50 of about 29,449 (247)

How metal substitution affects the enzymatic activity of catechol-o-methyltransferase. [PDF]

PLoS ONE, 2012
Catechol-O-methyltransferase (COMT) degrades catecholamines, such as dopamine and epinephrine, by methylating them in the presence of a divalent metal cation (usually Mg(II)), and S-adenosyl-L-methionine.
Manuel Sparta, Anastassia N Alexandrova
doaj   +1 more source

The genomics of neonatal abstinence syndrome [PDF]

, 2017
Significant variability has been observed in the development and severity of neonatal abstinence syndrome (NAS) among neonates exposed to prenatal opioids.
Cole, F. Sessions, Davis, Jonathan M, Wegner, Daniel J   +2 more
core   +3 more sources

Structural mechanism of S-adenosyl methionine binding to catechol O-methyltransferase. [PDF]

PLoS ONE, 2011
Methyltransferases possess a homologous domain that requires both a divalent metal cation and S-adenosyl-L-methionine (SAM) to catalyze its reactions. The kinetics of several methyltransferases has been well characterized; however, the details regarding ...
Douglas Tsao, Luda Diatchenko, Nikolay V Dokholyan   +2 more
doaj   +1 more source

Organic Cation Transporter 3 (OCT3) Is Localized to Intracellular and Surface Membranes in Select Glial and Neuronal Cells Within the Basolateral Amygdaloid Complex of Both Rats and Mice [PDF]

, 2016
Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin. OCT3 is expressed widely throughout the
Chan, June, Gasser, Paul J, Hurley, Matthew M., Pickel, Virginia M.   +3 more
core   +2 more sources

Serotonin-Induced Hypersensitivity via Inhibition of Catechol O-Methyltransferase Activity

Molecular Pain, 2012
The subcutaneous and systemic injection of serotonin reduces cutaneous and visceral pain thresholds and increases responses to noxious stimuli. Different subtypes of 5-hydroxytryptamine (5-HT) receptors are suggested to be associated with different types
Tsao Douglas, Wieskopf Jeffrey S, Rashid Naim, Sorge Robert E, Redler Rachel L, Segall Samantha K, Mogil Jeffrey S, Maixner William, Dokholyan Nikolay V, Diatchenko Luda   +9 more
doaj   +1 more source

Investigation of the effect of catechol-o-methyltransferase gene rs4680 polymorphism on trigeminal neuralgia susceptibility

The European Chemistry and Biotechnology Journal
Research has been conducted to explore the genetic basis of trigeminal neuralgia, a persistent pain condition that impacts the trigeminal nerve. COMT is an enzyme responsible for inactivating substances and hormones containing catechol and catecholamines.
Nuraleyna Akarsu, Ozlem Ozge Yilmaz, Beste Tacal Aslan, Fatma Gungor, Mehmet Gulluoglu, Guhan Dergin, Korkut Ulucan   +6 more
doaj   +1 more source

HUMAN CATECHOL-O-METHYLTRANSFERASE (COMT) ASSAY [PDF]

, 2011
Disclosed is an assay (method) to quantify the amounts of catecholamine-O-methyltransferase (COMT) protein in samples, such as extracts from cell cultures, body fluids, tissues, and environmental samples.

core  

Are Large Physiological Reactions to Acute Psychological Stress Always Bad for Health? [PDF]

, 2009
How we react physiologically to stress has long been considered to have implications for our health. There is now persuasive evidence that individuals who show large cardiovascular reactions to stress are at increased risk of developing cardiovascular ...
Acheson, Adolphs, Allen, Al’Absi, Al’Absi, Al’Absi, Anisman, Bachen, Barch, Barnett, Bechara, Beck, Blair, Bosch, Bosch, Bosch, Brydon, Buchanan, Cacioppo, Caldji, Carney, Carroll, Carroll, Carroll, Carroll, Carroll, Carroll, Carroll, Carroll, Caspi, Critchley, Cuthbert, Damasio, Damasio, De Boer, De Boer, Dhabhar, Dhabhar, Ditto, Drummond, Edwards, Edwards, Edwards, Edwards, Enoch, Everson, Everson, Fredrikson, Gagnon, Georgiades, Gianaros, Gianaros, Girdler, Glahn, Goldman, Grassi, Hemingway, Idler, Ishiguro, Kanitz, Kapuku, Kario, Kario, Kibler, Kirschbaum, Kirschbaum, Kirschbaum, Krantz, Lazarus, Leor, Lesch, Light, Lipsky, Liu, Lovallo, Lovallo, Lovallo, Lovallo, Lovallo, Lovallo, Lovallo, Lovallo, Lowe, Lynch, Maier, Manuck, Manuck, Manuck, Manuck, Markovitz, Matthews, Matthews, Meaney, Meaney, Meisel, Mesulam, Millan, Miller, Mischler, Moss, Muldoon, Murdison, Naqvi, Newman, Obrist, Panknin, Patterson, Patterson, Phillips, Phillips, Phillips, Phillips, Phillips, Plotsky, Pomerleau, Rohleder, Rolls, Roy, Schwartz, Sheffield, Silberman, Sims, Smith, Smolka, Sorocco, Straneva, Tentolouris, Tentolouris, Tofler, Treiber, Treiber, Trichopoulos, Tuchscherer, Turner, Ungerleider, Vandenbergh, Welle, Williams, Williams, Witte, Wulsin, York, Zgraggen, Zigmond, Zubieta   +144 more
core   +2 more sources

Catechol-O-Methyltransferase and 3,4-(±)-Methylenedioxymethamphetamine Toxicity [PDF]

Toxicological Sciences, 2014
Metabolism of 3,4-(±)-methylenedioxymethamphetamine (MDMA) is necessary to elicit its neurotoxic effects. Perturbations in phase I and phase II hepatic enzymes can alter the neurotoxic profile of systemically administered MDMA. In particular, catechol-O-methyltransferase (COMT) plays a critical role in determining the fraction of MDMA that is converted
Joseph M, Herndon, Aram B, Cholanians, Lucina E, Lizarraga, Serrine S, Lau, Terrence J, Monks   +4 more
openaire   +2 more sources

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source