Results 51 to 60 of about 29,449 (247)

Influence of COMT genotype and affective distractors on the processing of self-generated thought [PDF]

, 2014
The catechol-O-methyltransferase (COMT) enzyme is a major determinant of prefrontal dopamine levels. The Val158Met polymorphism affects COMT enzymatic activity and has been associated with variation in executive function and affective processing.
Bar-Haim, Barnett, Barnett, Braver, Braver, Burgess, Chen, Cools, Dickinson, Dumontheil, Dumontheil, Egger, Emma J. Kilford, Frith, Gilbert, Gogos, Goldman, Goldman-Rakic, Harrison, Iroise Dumontheil, Jacobs, Jaspar, Lachman, Ladouceur, Meyer-Lindenberg, Mier, Millan, Montag, Nicholas W. Wood, Ochsner, Palmatier, Pooley, Sarah-Jayne Blakemore, Skuse, Spielberger, Tottenham, Tunbridge, Wechsler, Williams, Williams, Witte   +40 more
core   +1 more source

Methyl conjugation in uraemia: catechol‐O‐methyltransferase. [PDF]

British Journal of Clinical Pharmacology, 1980
1 Erythrocyte (RBC) catechol‐9‐methyltransferase (COMT) activity is significantly higher in erythrocytes from uraemic patients on maintenance haemodialysis, 18.7 +/‐ 1.4 units/ml RBC (mean +/‐ s.e. mean, n = 22) than in the blood of randomly selected subjects, 12.0 +/‐ 0.2 units/ml (mean +/‐ s.e. mean, n = 557, P < 0.001).
P A, Pazmiño, R M, Weinshilboum
openaire   +2 more sources

Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT In Attention Deficit Hyperactivity Disorder (ADHD), methylphenidate is one of the most widely used drugs, in which patient response significantly impacts prognosis. This study aimed to characterize the molecular profile of 10 genes associated with methylphenidate therapy.
Aline Pasquini Santos, Tatiane Carinta de Souza, Kaio Evandro Cardoso Aguiar, Ana Caroline Alves da Costa, Natasha Monte, Juliana Carla Gomes Rodrigues, Giovanna Gilioli da Costa Nunes, Rita de Cássia Calderaro Coelho, Ândrea Ribeiro‐dos‐Santos, André Maurício Ribeiro dos Santos, Sandro José de Souza, Sidney Emanuel Batista dos Santos, Rommel Mario Rodriguez Burbano, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +14 more
wiley   +1 more source

Catechol-O-methyltransferase inhibition with tolcapone reduces the "wearing off" phenomenon and levodopa requirements in fluctuating parkinsonian patients. [PDF]

, 1997
BACKGROUND: More than 50% of patients with Parkinson's disease develop motor response fluctuations (the "wearing off" phenomenon) after more than five years of levodopa therapy.
Baas, H., Beiske, A.G., Ghika, J., Jackson, M., Oertel, W.H., Poewe, W., Ransmayr, G.   +6 more
core   +1 more source

Rational Design Strategies for Stimuli‐Responsive DNAzymes Using Modified and Artificial Nucleotides

Chemistry – A European Journal, EarlyView.
Activity control of RNA‐cleaving DNAzymes in response to external stimuli has attracted growing interest for applications in DNA‐based diagnostics, therapeutics, and dynamic DNA nanotechnology. This review summarizes rational design strategies for stimuli‐responsive DNAzymes using modified or artificial nucleotides, including split and caged DNAzymes ...
Yusuke Takezawa, Mitsuhiko Shionoya
wiley   +1 more source

Catechol-O-methyltransferase and breast cancer risk [PDF]

Carcinogenesis, 1998
Recent studies suggest that a polymorphism in catechol-O-methyltransferase (COMT) is associated with increased risk of breast cancer. Methylation by COMT is the principal pathway for inactivation of catechol estrogens, which are hypothesized to participate in estrogen-induced carcinogenesis.
R C, Millikan, G S, Pittman, C K, Tse, E, Duell, B, Newman, D, Savitz, P G, Moorman, R J, Boissy, D A, Bell   +8 more
openaire   +2 more sources

Comparative Bioequivalence and Safety Evaluation of Ibuprofen/Phenylephrine Hydrochloride Fixed‐Dose Combination Tablets in Healthy Chinese Volunteers

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This single‐center, randomized, open‐label bioequivalence program compared two fixed‐dose combination (FDC) tablets containing ibuprofen (200 mg) and phenylephrine hydrochloride (10 mg) from different manufacturers in healthy Chinese adults under fasting and fed conditions. A three‐period, partially replicated crossover design was used for the
Menghan Ye, Rui Zhang, Jing Wan, Jinping Zhou, Pengpeng Guo, Dianwen Yu, Peixia Li, Yani Liu, Shaojun Shi   +8 more
wiley   +1 more source

Genes of the serotonergic and dopaminergic pathways and their interaction affect the expression of Behavioural and Psychological Symptoms in Dementia (BPSD). [PDF]

, 2009
Although there is evidence for the involvement of genes of serotonergic and dopaminergic systems in the manifestation of the Behavioural and Psychological Symptoms in Dementia (BPSD), genetic association studies are contradictory.
Belinda Martin, Brian Lawlord, Gillian Hamilton, John Powell, Julie Williams, Michael Gill, Michael J. Owen, Michelle Lupton, Nicola Archer, Paul hollingworth, Petroula Proitsi, Simon Lovestone, Suzanne Reeves   +12 more
core   +1 more source

Assessment of Cellular Estrogenic Activity Based on Estrogen Receptor-Mediated Reduction of Soluble-Form Catechol-O-Methyltransferase (COMT) Expression in an ELISA-Based System [PDF]

, 2013
published_or_final_versio
Ho, SL, Ho, WL, Ho, WM, Kung, MHW, Liu, H, Lu, S, Ramsden, DB, Tse, HM   +7 more
core   +1 more source

Harnessing Free Radical Scavenging Potential of Caffeic Acid as a Nutraceutical—A Review

Food Safety and Health, EarlyView.
Caffeic acid has emerged as a promising bioactive molecule with multiple pharmacological properties, including antioxidant, antimicrobial, anti‐inflammatory, organ protective properties and metal‐chelating ability. This review emphasizes the dietary sources, structural characteristic, molecular mechanism underlying health promoting effects of caffeic ...
Pavitra Behra, Monika Bhadauria, Satendra Kumar Nirala   +2 more
wiley   +1 more source