Results 81 to 90 of about 29,449 (247)

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Developmental changes in human dopamine neurotransmission: cortical receptors and terminators

BMC Neuroscience, 2012
Background Dopamine is integral to cognition, learning and memory, and dysfunctions of the frontal cortical dopamine system have been implicated in several developmental neuropsychiatric disorders.
Rothmond Debora A, Weickert Cynthia S, Webster Maree J   +2 more
doaj   +1 more source

Catechol-O-Methyltransferase moderates effect of stress mindset on affect and cognition. [PDF]

PLoS ONE, 2018
There is evidence that altering stress mindset-the belief that stress is enhancing vs. debilitating-can change cognitive, affective and physiological responses to stress.
Alia J Crum, Modupe Akinola, Bradley P Turnwald, Ted J Kaptchuk, Kathryn T Hall   +4 more
doaj   +1 more source

Yale School of Public Health Symposium on tissue imaging mass spectrometry: illuminating phenotypic heterogeneity and drug disposition at the molecular level. [PDF]

, 2018
‘A picture is worth a thousand words’ is an idiom from the English language (‘borrowed’ from on old Chinese proverb) that conveys the notion that a complex idea can be succinctly and fully described by a single image. Never has this expression been truer
Andrén, PE, Caprioli, RM, Castellino, S, Charkoftaki, G, Duncan, MW, Goodwin, RJA, Johnson, CH, Rattray, NJW, Schey, KL, Shahidi-Latham, SK, Vasiliou, V, Veselkov, KA   +11 more
core   +3 more sources

Catechol-O-methyltransferase association with hemoglobin A1c [PDF]

Metabolism, 2016
Catecholamines have metabolic effects on blood pressure, insulin sensitivity and blood glucose. Genetic variation in catechol-O-methyltransferase (COMT), an enzyme that degrades catecholamines, is associated with cardiometabolic risk factors and incident cardiovascular disease (CVD).
Kathryn T. Hall, Kathleen A. Jablonski, Ling Chen, Maegan Harden, Benjamin R. Tolkin, Ted J. Kaptchuk, George A. Bray, Paul M. Ridker, Jose C. Florez, Kenneth J. Mukamal, Daniel I. Chasman   +10 more
openaire   +2 more sources

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Gestational kynurenine metabolites mediate effects of pregnancy adiposity on child negative affect

Journal of Child Psychology and Psychiatry, EarlyView.
Background Mounting evidence links increased adiposity during pregnancy and offspring risk for mental health disorders. Yet the mechanisms underlying this association remain poorly understood, limiting our ability to design effective interventions.
Hanna C. Gustafsson, Hanna R. Wright, Jorden E. Jacinto Schreeder, Joel T. Nigg, Elinor L. Sullivan   +4 more
wiley   +1 more source

Development of fed-batch profiles for efficient biosynthesis of catechol-O-methyltransferase

Biotechnology Reports, 2014
Catechol-O-methyltransferase (COMT, EC 2.1.1.6) plays a crucial role in dopamine metabolism which has intimately linked this enzyme to some neurodegenerative diseases, such as Parkinson's disease.
G.M. Espírito Santo, A.Q. Pedro, D. Oppolzer, M.J. Bonifácio, J.A. Queiroz, F. Silva, L.A. Passarinha   +6 more
doaj   +1 more source

Interaction between cytochrome P450 2A6 and Catechol-O-Methyltransferase genes and their association with smoking risk in young men

Behavioral and Brain Functions, 2017
Background Although some effects of gene–gene interactions on nicotine–dopamine metabolism for smoking behavior have been reported, polymorphisms of cytochrome P450 (CYP) 2A6 and catechol-O-methyltransferase (COMT) have not been studied together to ...
Wei-Chih Ou, Yi-Chin Huang, Chih-Ling Huang, Min-Hsuan Lin, Yi-Chun Chen, Yi-Ju Chen, Chen-Nu Liu, Mei-Chih Chen, Ching-Shan Huang, Pei-Lain Chen   +9 more
doaj   +1 more source

COMT Val 158 Met polymorphism is associated with nonverbal cognition following mild traumatic brain injury [PDF]

, 2015
Mild traumatic brain injury (mTBI) results in variable clinical outcomes, which may be influenced by genetic variation. A single-nucleotide polymorphism in catechol-o-methyltransferase (COMT), an enzyme which degrades catecholamine neurotransmitters, may
Barber, Jason, Burchard, Esteban G, Burke, John F, Diaz-Arrastia, Ramon, Eng, Celeste, Ferguson, Adam R, Gardner, Raquel C, Hu, Donglei, Lingsma, Hester F, Manley, Geoffrey T, McAllister, Thomas W, Mukherjee, Pratik, Oh, Sam S, Okonkwo, David O, Puccio, Ava M, Rosand, Jonathan, Satris, Gabriela G, Sharma, Sourabh, Sorani, Marco D, Tarapore, Phiroz E, Temkin, Nancy R, TRACK-TBI Investigators, Valadka, Alex B, Wang, Kevin KW, Winkler, Ethan A, Yue, John K, Yuh, Esther L   +26 more
core   +1 more source