Results 291 to 300 of about 55,807 (381)

Pathogenesis of Chemical Leukoderma and Chemical‐Induced Vitiligo

The Journal of Dermatology, EarlyView.
ABSTRACT Leukoderma/vitiligo is a serious pigmentary disorder that notably impairs the patient's quality of life. In particular, chemical leukoderma (CL)/vitiligo refers to acquired depigmentation of the skin induced by exposure to certain chemicals. In this review, the term “CL” is defined as the temporary, localized loss of pigmentation at the site ...
Yasutaka Kuroda, Lingli Yang, Ichiro Katayama   +2 more
wiley   +1 more source

Engineering non-P450 3-hydroxylase for <i>de novo</i> synthesizes catechol-containing compounds in <i>Escherichia coli</i>. [PDF]

Synth Syst Biotechnol
Zheng XR, Li GP, Chen QH, Liu JZ.
europepmc   +1 more source

Predicting Response to Pro‐Cognitive Interventions in Mood Disorders: A Systematic Review by the International Society for Bipolar Disorders Targeting Cognition Task Force

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Major depressive disorder (MDD) and bipolar disorder (BD) are often associated with persistent cognitive deficits that impair psychosocial functioning. While pro‐cognitive interventions show promise, trial findings are inconsistent, potentially due to baseline factors influencing treatment response.
Dimosthenis Tsapekos, Michail Kalfas, Johanna M. Schandorff, Caterina del Mar Bonnin, Christopher R. Bowie, Vicent Balanzá‐Martínez, Katherine E. Burdick, Andre F. Carvalho, Annemieke Dols, Katie Douglas, Peter Gallagher, Gregor Hasler, Lars V. Kessing, Hanne L. Kjærstad, Beny Lafer, Kathryn E. Lewandowski, Carlos López‐Jaramillo, Anabel Martinez‐Aran, Roger S. McIntyre, Richard J. Porter, Scot E. Purdon, Ayal Schaffer, Paul R. A. Stokes, Tomiki Sumiyoshi, Ivan J. Torres, Tamsyn E. Van Rheenen, Lakshmi N. Yatham, Jeff Zarp, Allan H. Young, Eduard Vieta, Kamilla W. Miskowiak   +30 more
wiley   +1 more source

Molecular Determinants of Optical Modulation in ssDNA-Carbon Nanotube Biosensors. [PDF]

ACS Nano
Krasley AT, Chakraborty S, Vuković L, Beyene AG.   +3 more
europepmc   +1 more source

Rare but relevant: MDMA and hyponatraemia

Addiction, EarlyView.
Abstract Conventionally used for its stimulant, empathogenic and entactogenic effects, 3,4‐methylenedioxymethamphetamine (MDMA, ecstasy) is one of the most commonly used psychoactive drugs, specifically among young adults and in nightlife and recreational party contexts.
Maria Rita Garcia, Nelson G. M. Gomes, Diana Dias‐da‐Silva   +2 more
wiley   +1 more source

The Mechanism of Fraxetin as a Sustainable Fungicide for Larch Shoot Blight: Lipid Peroxidation and Oxidative Stress in <i>Neofusicoccum laricinum</i>. [PDF]

J Fungi (Basel)
Zhang S, Zhang R, Xia R, Chen X, Chen J, Yang Y, Mujtaba M, Li D, Wang F.   +8 more
europepmc   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Targeting Melanin Production: The Safety of Tyrosinase Inhibition. [PDF]

Int J Mol Sci
Erler S, Kolbe L, Najjar A, Schepky A, Kamal A, Lange D, Rogers T.   +6 more
europepmc   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

De Novo Design and Asymmetric Synthesis of a <i>C</i>-1/2 Benzodioxin Fused Glycoside Analogue of Lincomycin. [PDF]

Org Lett
Hicks I, Moradei R, Chiaraviglio L, Aljahdali AZ, Donthiri RR, Kirby JE, O'Doherty GA.   +6 more
europepmc   +1 more source