Results 71 to 80 of about 7,970 (248)

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Microbial Degradation of Chloroaromatics: Use of the meta-Cleavage Pathway for Mineralization of Chlorobenzene [PDF]

, 1997
Pseudomonas putida GJ31 is able to simultaneously grow on toluene and chlorobenzene. When cultures of this strain were inhibited with 3-fluorocatechol while growing on toluene or chlorobenzene, 3-methylcatechol or 3-chlorocatechol, respectively ...
Kasberg, Thomas,, Agteren, Martin H. van,, Kaschabek, Stefan R., Mars, Astrid E.,, Mars, Astrid E., Janssen, Dick B., Reineke, Walter,, Reineke, Walter, Agteren, Martin H. van, Kaschabek, Stefan R.,, Kasberg, Thomas, Janssen, Dick B.,   +11 more
core   +1 more source

Effect of particle size on the reactivity of quantum size ZnO nanoparticles and charge-transfer dynamics with adsorbed catechols

, 2003
The photophysics and reactivity of quantum size ZnO nanoparticles have been studied using static and time-resolved emission and absorption spectroscopy.
Ghosh, Hirendra N., Ramakrishna, G.
core   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

Probing the Surface Adsorption and Photocatalytic Degradation of Catechols on TiO₂ by Solid-State NMR Spectroscopy

, 2016
The local structure of the TiO2 surface modified with electron-donating bidentate ligands, such as catechols, has been investigated by solid-state NMR spectroscopy.
Yoshio Takai (2536720), Takashi Tachikawa (1269738), Sachiko Tojo (1262253), Mamoru Fujitsuka (1262256), Tetsuro Majima (1262259)   +4 more
core   +1 more source

A Blood‐Derived Double‐Network Hydrogel with Robust Wet Adhesion for Keratinized Mucosa Regeneration via Neutrophil Phenotype Reprogramming and Mechanophysical Niche Modulation

Advanced Science, EarlyView.
The iPRF‐MA/Alg‐NHS/Lut@EGCG (PGAE) double‐network hydrogel achieves durable wet adhesion in the oral environment. It simultaneously reprograms neutrophils from NETosis to phagocytosis for biofilm clearance, and activates the FAK‐RhoA‐YAP mechanotransduction pathway in gingival fibroblasts to drive extracellular matrix remodeling, thereby promoting ...
Sicong Ren, Xinting Yang, Jingxia Chen, Yihan Wang, Jian Feng, Jing Zhou, Jiaxin Luo, Jingjie Zhai, Quan Lin, Yanmin Zhou   +9 more
wiley   +1 more source

Crystal structure, thermal, redox, and EPR studies of copper(II) complexes with catechol-based quaternary ammonium salts

Chimica Techno Acta
Quaternary ammonium salts (QASs), acylhydrazones and catechols are well known for their antimicrobial, antioxidant and antitumor properties. Complexation of acylhydrazones and catechols with Cu(II) ions potentially leads to obtaining compounds with ...
Azamat Bikmukhametov, Маksim Zhernakov, Mikhail Bukharov, Yury Kuzin, Daut Islamov, Artur Khannanov, Alexander Gerasimov, Liana Zubaidullina, Alexander Rodionov, Pavel Padnya, Ivan Stoikov   +10 more
doaj   +1 more source

Biomimetic Hydrogel System Targeting S100A8 Centered Neuroimmune Crosstalk and Hypoxia Induced Neuronal Injury

Advanced Science, EarlyView.
A biomimetic hydrogel (HPC@Gel) was developed for traumatic brain injury repair by combining oxygen‐carrying hemoglobin nanoparticles and anti‐inflammatory carbon quantum dots within a brain‐like matrix. The system alleviated hypoxia, reduced harmful neuroimmune signaling, protected neurons, supported neural regeneration, and improved neurological and ...
Peng Liu, Xiaoyang Wu, Xiaoyin Liu, Yuyan Wang, Shichao Jiang, Kai Wu, Gaowei Li, Jie Ding, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan, Liangxue Zhou   +12 more
wiley   +1 more source

Thermoresponsive Dendronized Polypeptides Showing Switchable Recognition to Catechols

, 2016
A new class of thermoresponsive dendronized polypeptides was prepared through highly efficient oxime ligation between oxyamino-substituted polylysines and aldehyde-cored oligoethylene glycol (OEG) dendrons. Their secondary structures and thermoresponsive
Afang Zhang (1422715), Kun Liu (148201), Wen Li (143214), Jiatao Yan (1422718), Huang Shi (1422712)   +4 more
core   +1 more source