Results 261 to 270 of about 1,516,973 (367)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Divergent roles of visual structure and conceptual meaning in scene detection and categorization. [PDF]

J Vis
Aronson S, Adkins MS, Greene MR.
europepmc   +1 more source

Changes in the shape of the archaeological grape pips from the 25 studied archaeological sites, categorized into seven chronological periods, distinguishing seeds according to their classification into wild and domestic types, and comparison to current wild and domestic pip shapes.

Mariano Ucchesu (2270875), Sarah Ivorra (412829), Vincent Bonhomme (447924), Thierry Pastor (412831), Biancamaria Aranguren (21168833), Gianluigi Bacchetta (568647), Giovanna Bosi (2897687), Andrea Cardarelli (6191108), Anna Depalmas (21168836), Gianni de Zuccato (21168839), Assunta Florenzano (674765), Juan Francisco Gibaja-Bao (21168842), Marta Mariotti Lippi (9285738), Niccolò Mazzucco (8786693), Anna Maria Mercuri (12535314), Mario Mineo (8786702), Miria Mori Secci (21168845), Renato Nisbet (21168848), Gianluca Pellacani (21168851), Paola Perazzi (21168854), Mauro Rottoli (21168857), Luciano Salzani (6191111), Marco Sarigu (8124101), Alessandro Usai (21168860), Laurent Bouby (412825)   +24 more
openalex   +1 more source

Interdisciplinary Introduction to Categorization

, 2018
Stéphane J. Baele, Amie L. Thomasson, Dvora Yanov, T. Serre   +3 more
openalex   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

What type of relationship is learned during visual statistical learning? [PDF]

PLoS One
Nazlı İ, de Lange FP.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Dental Crowding Categorization Network (DCC-Net): Explainable deep learning system for automatic categorization of dental crowding on intraoral photographs. [PDF]

Korean J Orthod
Wang R, Deng Y, Cheng F, Zhang J, Fan C, Fu R, Li J, Jiang F.   +7 more
europepmc   +1 more source

Dynamics of speech sound categorization for continua defined by spectral vs. duration contrast

, 2009
Ran Liu, Jason D. Zevin
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source