Results 101 to 110 of about 3,612,301 (282)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

C*-Algebras over Topological Spaces: The Bootstrap Class

open access: yes, 2008
We carefully define and study C*-algebras over topological spaces, possibly non-Hausdorff, and review some relevant results from point-set topology along the way.
Meyer, Ralf, Nest, Ryszard
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

CLDRNet: A Difference Refinement Network Based on Category Context Learning for Remote Sensing Image Change Detection

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
In recent years, change detection (CD) of optical remote sensing images has made remarkable progress through using deep learning. However, current CD deep learning methods are usually improved from the semantic segmentation models, and focus on enhancing
Ling Wan, Ye Tian, Wenchao Kang, Lei Ma
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Assessments of Climate Literacy and Climate Change Awareness

open access: yesJurnal Presipitasi
Climate change has become a serious threat to all humans, with impacts already being felt throughout the planet. One effort in climate change education is to improve students' climate literacy and climate change awareness.
Cincin Cintami   +3 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Auditory preattentive processing of Thai vowel change perception in consonant-vowel (CV) syllables [PDF]

open access: yesSongklanakarin Journal of Science and Technology (SJST), 2004
Event-related potential (ERP) responses to infrequently presented spoken deviant syllables /pi/ among repetitive standard /pc/ syllables were recorded in Thai subjects who ignored these stimuli while reading books of their choices.
Naiphinich Kotchabhakdi   +2 more
doaj  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

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