Results 101 to 110 of about 134,831 (309)

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Serial dependence in a simulated clinical visual search task. [PDF]

, 2019
In everyday life, we continuously search for and classify objects in the environment around us. This kind of visual search is extremely important when performed by radiologists in cancer image interpretation and officers in airport security screening ...
Kristjánsson, Árni, Manassi, Mauro, Whitney, David   +2 more
core  

The Negativity of Negative Propositions [PDF]

, 2012
The problem of truthmakers for negative propositions was introduced by Bertrand Russell in 1918. Since then the debate has mostly been concerned with whether to accept or reject their existence, and little has been said about what it is that makes a ...
Kühl, Carl Erik
core   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

3D QR Code-Based Indonesian Cultural lind Map to Critical Thinking Ability

Thinking Skills and Creativity Journal
Learning that still uses the teacher centered method results in students' critical thinking abilities being low. This research aims to develop a 3D learning media for a QR code-based map of Indonesian cultural blindness to improve students' critical ...
I Made Sukiana, I Made Suarjana, I Made Tegeh   +2 more
doaj   +1 more source

Biologically inspired distributed machine cognition: a new formal approach to hyperparallel computation [PDF]

, 2007
The irresistable march toward multiple-core chip technology presents currently intractable pdrogramming challenges. High level mental processes in many animals, and their analogs for social structures, appear similarly massively parallel, and recent ...
Wallace, Rodrick
core  

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

How a turn to critical race theory can contribute to our understanding of 'race', racism and anti-racism in sport [PDF]

, 2010
As long as racism has been associated with sport there have been consistent, if not coordinated or coherent, struggles to confront its various forms. Critical race theory (CRT) is a framework established to challenge these racialized inequalities and ...
Ahmed S, Back L, Bell D, Beneton P, Blum L, Bonilla-Silva E, Bonnett A, Bonnett A, Burdsey D, Crenshaw K, Cross M, Delgado R, Essed P, Gillborn D, Gilroy P, Gilroy P, Glover K, Goldberg D, Griffin JH, Hylton K, Hylton K, Hylton K., Kevin Hylton, Long J, Long J, Majors R, Murji K, Nanton P, Omi M., Parker L, Reed P, Sterkenburg J, Stofile M, Stofile M., The Guardian, Wieviorka M, Williams J, Winant M, Zirin D   +38 more
core   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Does Familiarity breed inattention? Why drivers crash on the roads they know best [PDF]

, 2012
This paper describes our research into the nature of everyday driving, with a particular emphasis on the processes that govern driver behaviour in familiar, well - practiced situations.
Charlton, Samuel G., Starkey, Nicola J.
core