Results 71 to 80 of about 134,831 (309)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Clinical and epidemiological characterization of visually impaired patients due to neuro-ophthalmologic alterations

Neurology Perspectives, 2022
Background: Several neurological pathologies affect visual functions (transitorily or permanently). However, the magnitude and epidemiological behavior of these as potential causes of low vision and blindness are unknown.
S.M. Ocampo, L.M. Pineda, S.S. Goldfeder, M.D.M. Tamayo, L.M. Ordóñez, M.L. Muñoz, L.M. Rodríguez, J.C. Suárez   +7 more
doaj   +1 more source

Awareness regarding eye donation among stakeholders in Srikakulam district in South India [PDF]

, 2014
Background There is a huge need for the availability of transplantable donor corneas worldwide to reduce the burden of corneal blindness due to corneal opacity.
Jalbert, I., Ramachandran, B. P., Ronanki, V. R., Sheeladevi, S.   +3 more
core   +4 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Head or skull injury? Consequences of using mistranslated ICD diagnosis category: Multicenter, blinded, randomized controlled analysis

Journal of Forensic and Legal Medicine
Emergency care units in Hungary treat approximately 140-180 thousand head injuries of varying se'verity each year. These head injuries are mainly caused by traffic accidents, assaults, or domestic accidents. The outpatient care record contains details about the circumstances and underlying mechanisms of the head injury, the results of physical and ...
Katalin Fogarasi, Gábor Simon, Attila Gátos, Gábor Gyenes, Péter Gergely, Zoltán Patonai   +5 more
openaire   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

The Cell-Matrix Interface: a Possible Target for Treating Retinal Vascular Related Pathologies

Journal of Ophthalmic & Vision Research, 2012
Retinal vasculature related pathologies account for a large proportion of global blindness. Choroidal neovascularization accompanying age-related macular degeneration is the largest cause of blindness in people over the age of 65 years, proliferative ...
Gopalan Gnanaguru, William J Brunken
doaj  

Low Vision Rehabilitation in Patients with Hereditary Retinal Dystrophy

Türk Oftalmoloji Dergisi, 2015
Objectives: To examine the methods of low vision rehabilitation in patients with hereditary retinal dystrophy. Materials and Methods: This study was conducted in Ankara University Faculty of Medicine, Ophthalmology Department of Low Vision ...
İkbal Seza Petriçli, Aysun İdil Merdoğan, Zuhal Özen Tunay, Özdemir Özdemir   +3 more
doaj   +1 more source

Neural correlates of perceiving emotional faces and bodies in developmental prosopagnosia: an event-related fMRI-study. [PDF]

PLoS ONE, 2008
Many people experience transient difficulties in recognizing faces but only a small number of them cannot recognize their family members when meeting them unexpectedly. Such face blindness is associated with serious problems in everyday life.
Jan Van den Stock, Wim A C van de Riet, Ruthger Righart, Beatrice de Gelder   +3 more
doaj   +1 more source

When Good Observers Go Bad: Change Blindness, Inattentional Blindness, and Visual Experience [PDF]

, 2000
Several studies (e.g., Becklen & Cervone, 1983; Mack & Rock, 1998; Neisser & Becklen, 1975) have found that observers attending to a particular object or event often fail to report the presence of unexpected items.
Rensink, Ronald A.
core   +1 more source