Results 121 to 130 of about 1,546,902 (293)

Interobserver Agreement for Endometrial Cancer Characteristics Evaluated on Biopsy Material

open access: yesObstetrics and Gynecology International, 2012
A shift toward a disease-based therapy designed according to patterns of failure and likelihood of nodal involvement predicted by pathologic determinants has recently led to considering a selective approach to lymphadenectomy for endometrial cancer ...
S. Nofech-Mozes   +7 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Shifts in treatment initiation patterns among newly diagnosed multiple sclerosis patients in Germany: a claims data analysis from 2017 to 2022

open access: yesTherapeutic Advances in Neurological Disorders
Background: Early use of high-efficacy therapies (EHT) in multiple sclerosis (MS) is a promising but novel treatment strategy. Its adoption in Germany’s MS care warrants further research.
Ann-Sophie Stratil   +4 more
doaj   +1 more source

Domain-Adaptive Underwater Target Detection Method Based on GPA + CBAM

open access: yes水下无人系统学报
Underwater target detection is often more susceptible to domain shift and reduced detection accuracy. In response to this phenomenon, this article proposed a domain-adaptive underwater target detection method based on graph-induced prototype alignment ...
Qidong LIU   +4 more
doaj   +1 more source

Introducing the idea of entropy to the ontological category shift theory for conceptual change: The case of heat and sound

open access: yesPhysical Review Physics Education Research, 2019
In the present theoretical study, we introduce the entropy concept into Chi’s ontological shift theory. Chi distinguishes between two categories of process phenomena, direct and emergent, and claims that incorrectly considering emergent processes as ...
Alexander Volfson   +2 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Representational Shifts in Children Aged 6 to 9

open access: yesКультурно-историческая психология
The experiment tested the hypothesis regarding the influence of categorical labels on image memory in children aged 6–9 years. Previous literature describes the effect of representational shift, which manifests as impaired recognition of
A.A. Kotov, T.N. Kotova, M.D. Afonin
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

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