Extrapolation of lung pharmacokinetics of bedaquiline across species using physiologically-based pharmacokinetic modelling. [PDF]
Br J Clin PharmacolAims Bedaquiline (BDQ) is a first‐in‐class diarylquinoline (DARQ) and a potent anti‐tuberculosis drug, vital in combating multi‐drug resistant tuberculosis (TB). Understanding its lung pharmacokinetics (PK) across species is crucial for effective clinical translation.
Karakitsios E +2 more
europepmc +2 more sources
Buildings, 2023 The behavior of steel frame buildings under progressive collapse conditions depends on a combination of several parameters, including the interplay between different collapse resistance mechanisms that are mobilized in different structural components ...
Panagiotis Stylianidis, John Bellos
doaj +1 more source
EXPERIMENTAL AND NUMERICAL ANALYSIS OF CLT FLOOR SUBASSEMBLIES UNDER CATENARY ACTION
World Conference on Timber Engineering (WCTE 2023), 2023 Behaviour under combined axial tension and out-of-plane bending, typically observed in catenary action after loss of a support, was investigated on Cross Laminated Timber (CLT) floors. Uni-axial tension tests as well as combined tension and bending tests on CLT component and floor subassembly levels with screw butt joints and varying boundary ...
Alicja Przystup +3 more
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Progressive Collapse Resistance Analysis of Precast Concrete Frames with Infill Walls
Shanghai Jiaotong Daxue xuebao, 2021 The infill wall has a significant influence on the progressive collapse resistance of the precast concrete (PC) frame, and there is no corresponding design method at present.
ZHANG Jingbo, YANG Jian, WANG Feiliang
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Performance of bolted steel-beam to CFST-column joints using stiffened angles in column-removal scenario [PDF]
, 2019 This paper presents three experimental investigations on the performance of steel-beam to CFST-column joints using stiffened angle, long bolts and fin plate under a middle column removal scenario. Three specimens were designed and tested.
Fu, F., Gao, S., Guo, L., Xu, M.
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Progressive collapse performance of shear strengthened RC frames by nano CFRP
Nanotechnology Reviews, 2022 To investigate the effect of nano carbon-fiber-reinforced polymer (nano CFRP) on retrofitting reinforced concrete (RC) structures, this article presented the progressive collapse performance of two half-scale four-bay RC frames including one control ...
Chen Weihong +4 more
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Progressive collapse analysis of reinforced concrete in buildings L-shaped plan [PDF]
Journal of Structural and Construction Engineering, 2018 One of the most important issues discussed structural passive defense is progressive collapse. Progressive collapse occurs the sudden destruction caused by the deliberate structural member by accidents or disasters, such as earthquakes and terrorist ...
Hamze Rouhi, Ali Kheyroddin
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Ultimate behavior of idealized composite floor elements at ambient and elevated temperature [PDF]
, 2009 This paper is concerned with the ultimate behavior of composite floor slabs under extreme loading situations resembling those occurring during severe building fires.
Cashell, KA +2 more
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Experimental and Numerical Investigation on Progressive Collapse Resistance of Post-tensioned Precast Concrete Beam-Column Sub-assemblages [PDF]
, 2020 In this paper, four 1/2 scaled precast concrete (PC) beam-column sub-assemblages with high performance connection were tested under push-down loading procedure to study the load resisting mechanism of PC frames subjected to different column removal ...
Feng, D-C. +4 more
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Active Control of Contact Force for a Pantograph-Catenary System
Shock and Vibration, 2016 The performance of the high speed trains depends critically on the quality of the contact in the pantograph-catenary interaction. Maintaining a constant contact force needs taking special measures and one of the methods is to utilize active control to ...
Jiqiang Wang
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