Results 41 to 50 of about 430,791 (198)

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Gastric artery embolization: studying the effects of catheter type and injection method on microsphere distributions within a benchtop arterial model

BioMedical Engineering OnLine, 2020
Aims The objective of the study is to investigate the effect of catheter type and injection method on microsphere distributions, specifically vessel targeting accuracy.
Shaphan R. Jernigan, Jason A. Osborne, Gregory D. Buckner   +2 more
doaj   +1 more source

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

Peripherally Inserted Central Catheter by Interventional Nephrologists: Experiences from a Single Center

International Journal of General Medicine, 2022
A Young Kim, Jun Young Do, Kyu Hyang Cho, Jong Won Park, Seok Hui Kang Division of Nephrology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Republic of KoreaCorrespondence: Seok Hui Kang, Division of Nephrology ...
Kim AY, Do JY, Cho KH, Park JW, Kang SH
doaj  

Fast Hydrogel Micro‐Actuators Driven by Electric Fields

Advanced Materials, EarlyView.
We report the fabrication of chemically programmable electroactuating microstructures through the first integration of two‐photon polymerization with electrically actuated gelatin methacrylate‐based hydrogels. By tailoring the charge of the polymer network, we demonstrate programmable polarity‐dependent bending, enabling microstructures that ...
Annaël Sort‐Montenegro, Jason M. Delente, Žiga Roblek, Yekaterina Tskhe, Luke Dowling, Colm Delaney, Larisa Florea   +6 more
wiley   +1 more source

Influence Factors Analyses of PICC‐Related Bloodstream Infection, PICC‐Related Venous Thrombosis, and Infected Puncture Site and Their Influence on Cancer Patients' Death: A Retrospective Cross‐Sectional Study

Cancer Medicine
Purpose This study aimed to analyze the influence factors affecting catheter‐related bloodstream infection, catheter‐related thrombosis and catheter‐related local complication, respectively, and to explore the relationship among them, as well as the ...
Guizhen Weng, Xiaolan Wu, Suhui Zheng
doaj   +1 more source

Lab‐in‐a‐Tube System Integrating Hierarchically Wrinkled Electrodes and DNAzyme‐Functionalized Beads for Diagnosis of Clostridioides difficile Infection

Advanced Materials, EarlyView.
The point‐of‐care diagnosis of Clostridioides difficile infection remains challenging due to reliance on slow culture and amplification‐based methods. A lab‐in‐a‐tube electrochemical biosensor integrating DNAzymes, antifouling magnetic beads, and a hierarchically structured flow cell enables amplification‐ and culture‐free detection directly in stool ...
Survanshu Saxena, Soyeon Lee, Youngeun Choi, Jonathan L'Heureux‐Hache, Jiaying Liu, Sadman Sakib, Sara M. Imani, Marek Smieja, Yingfu Li, Todd Hoare, Leyla Soleymani   +10 more
wiley   +1 more source

Deep‐Tissue Light Generation via Whispering Gallery Mode Lasing From a Commercial Nylon Fiber for Biomedical Applications

Advanced Materials Technologies, EarlyView.
A dyed nylon fiber is implemented inside the scattering phantom and skin tissue. The deep‐tissue light generation via whispering gallery mode lasing is demonstrated, achieving a depth of >50 times transport mean free path in scattering phantom and 3 mm beneath skin.
Dongqin Ni, Florian Klämpfl, Fernando Lahoz, Michael Schmidt, Martin Hohmann   +4 more
wiley   +1 more source

Catheter detection by transthoracic echocardiography during placement of peripherally inserted central catheters: a real-time method for eliminating misplacement [PDF]

Acute and Critical Care
Background Although guidelines and protocols are available for central venous access, existing methods lack specificity and sensitivity, especially when placing peripherally inserted central catheters (PICCs).
Yong Chae Jung, Man-shik Shim, Hee Sun Park, Min-Woong Kang   +3 more
doaj   +1 more source