Results 81 to 90 of about 60,986 (335)

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

EduBlogs as metaphor

open access: yesInternational Review of Research in Open and Distributed Learning, 2009
This presentation will discuss a number of recent case studies, contrast examples of private and public edublogs, and explore issues such as learner and instructor roles and responsibilities, learner choices, ethical considerations, learning goals ...
Glenn Groulx
doaj   +1 more source

Translating transitional justice: the Solomon Islands Truth and Reconciliation Commission [PDF]

open access: yes, 2014
This paper contends that although the Solomon Islands Truth and Reconciliation Commission replicated the structure and operation of a truth commission based on a globalised and placeless theory of best practice in transitional justice, it was not ...
Louise Vella
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Evaluation of Therapeutic Effect of Jichuanjian on Cathartic Colon

open access: yesIranian Journal of Public Health, 2016
No Abstract.
Mingdong HUO   +4 more
doaj  

«L'alto furor di quel conte adirato». The Anger in the «Inamoramento de Orlando»

open access: yesGriseldaonline, 2019
The essay aims to investigate the theme of anger in Boiardo’s Inamoramento di Orlando. Starting from the occurrences of the terms ‘anger’, ‘anger’, ‘fury’, and their meanings, the analysis focuses on the physiognomy of anger, within the poem of Boiard ...
Elisa Curti
doaj   +1 more source

The sentimental novel as Trostschrift: Johann Martin Miller’s Siegwart. Eine Klostergeschichte (1776) [PDF]

open access: yes, 2010
Late eighteenth-century consolatory texts for bereavement employed traditional consolatory arguments, but also set new emphasis on sympathy, on a recognition of the individuality of the sufferer and on the benefits of an entertaining or ‘playful ...
Richards, Anna
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

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