Results 101 to 110 of about 8,483 (312)

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

Archaeological Investigations for Proposed Trail Rehabilitation within Mammoth Cave [PDF]

open access: yes, 2013
In 2008, staff from the University of Kentucky Program for Archaeological Research (UK-PAR) and the Illinois State Museum Society (ISMS) conducted archaeological and paleontological investigations at Mammoth Cave National Park in advance of proposed ...
Ahler, Steven R., Crothers, George M.
core   +1 more source

Landscape of BRAF transcript variants in human cancer

open access: yesMolecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda   +5 more
wiley   +1 more source

Chewing the fat on veterinary toxicology: The path to discovery [PDF]

open access: yes, 2015
DuHadway   +10 more
core   +2 more sources

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren   +16 more
wiley   +1 more source

Effect of different drying methods and solvent ratios on biological activities of Phyllanthus acidus extracts [PDF]

open access: yes, 2017
The main purpose of this study was to evaluate the antioxidant and α-glucosidase inhibitory activities of Phyllanthus acidus. The P. acidus fruits were dried using three different methods, namely oven (OD), air (AD) and freeze (FD) dryings and extracted ...
A. G., Siti Zulaikha   +5 more
core  

TRPM8 levels determine tumor vulnerability to channel agonists

open access: yesMolecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo   +18 more
wiley   +1 more source

Herald of Osteopathy, August 1924 [PDF]

open access: yes, 1924
Articles in this issue include: Therapeutic Nuggets by George W. Goode, D.O. Editorial A Real Doctor by J.H. Styles, Jr., D.O. “Crutches for Sale” by Asa Willard, D.O. The Untimely Death of Calvin Coolidge, Jr. by Geo W. Reid, D.O.
Herald of Osteopathy
core   +1 more source

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