Results 61 to 70 of about 541,369 (251)
β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
Advanced Science, EarlyView.β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto +20 more
wiley +1 more source
Analysing the problems of reproducing the mineral resource base of scarce strategic minerals
Записки Горного институтаThe results of studying the scarcity of strategic minerals in the Russian Federation are presented, domestic consumption of which is largely provided by forced imports and/or stored reserves.
Natalya V. Pashkevich +3 more
doaj
Effect of explosive detonation velocity on the degree of rock pre-fracturing during blasting
Горные науки и технологииAt many quarries for the extraction of building stone there is a problem of increased output of fines after all stages of crushing and grinding, which leads to a decrease in the economic performance of mining enterprises.
Sergei V. Khokhlov +3 more
doaj +1 more source
Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro
Advanced Science, EarlyView.The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel +15 more
wiley +1 more source
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
Записки Горного институтаThe possibility of discovering oil and gas occurrences at great (more than 5 km) and super-great (more than 6 km) depths is considered in two aspects. The first one is the preservation conditions of large hydrocarbon accumulations forming at depths to 4 ...
Oleg M. Prishchepa +3 more
doaj
Comments on the September 29, 2014 FSB Consultative Document, ‘Cross-Border Recognition of Resolution Action’ [PDF]
, 2014 This CIGI Paper No. 51 was released on December 3, 2014 by the Centre for International Governance Innovation (CIGI) as a response to the Financial Stability Board’s (FSB) Consultative Document, “Cross-Border Recognition of Resolution Action ...
Jewett, Mark +4 more
core +1 more source
GLS1 Orchestrates Exosome‐Mediated Tumor‐Endothelial Communication to Facilitate Angiogenesis
Advanced Science, EarlyView.This study reveals a previously unappreciated, non‐metabolic function of GLS1 in the control of tumor angiogenesis via exosome‐mediated CAV1‐TNC signaling, indicating that therapeutic targeting of GLS1 may offer a dual benefit by simultaneously suppressing tumor metabolic activity and angiogenic processes in head and neck cancer. ABSTRACT Glutaminase 1
Jianqiang Yang +9 more
wiley +1 more source
Записки Горного институтаWater- and oil-based drilling fluids are polydisperse non-Newtonian systems, the stress state of which is adequately described by the Herschel – Bulkley rheological model.
Vasiliy I. Nikitin +3 more
doaj
Increasing the efficiency of an industrial enterprise
Современная наука и инновацииThe active development of technologies requires new approaches in planning the activities of enterprises. To identify «weak points» in the company, it is recommended to use methods of system analysis.
M. A. Vishnyakova +3 more
doaj +1 more source