Results 151 to 160 of about 717,783 (259)

Clinical Evaluation of the Effectiveness of Digital Peroral Cholangioscopy‐Guided Lithotripsy for Difficult Bile Duct Stones

open access: yesJournal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background and Aims Peroral cholangioscopy‐guided lithotripsy (POCS‐L) has emerged as a treatment option for difficult bile duct stones (DBDSs), but detailed evidence remains limited. This study evaluated its effectiveness, safety, and risk factors for adverse events (AEs).
Hirohito Minami   +9 more
wiley   +1 more source

Methodological progress note: Descriptive, predictive, and causal observational studies

open access: yesJournal of Hospital Medicine, EarlyView.
Abstract Observational data can be used to answer descriptive, predictive, and causal questions. Analysis of observational data can be challenging and may require complex analytical methods to produce meaningful, unbiased results; for example, when addressing confounding in causal studies.
Brett P. Dyer   +2 more
wiley   +1 more source

Understanding and interpreting composite outcomes in clinical research

open access: yesJournal of Hospital Medicine, EarlyView.
Abstract Composite outcomes combine multiple endpoints into a single measure. They can capture overall treatment effects and increase statistical power, but have important interpretive challenges. Components of the outcome may vary in clinical importance, frequency, and treatment effect.
Mari Takashima   +3 more
wiley   +1 more source

LRP-1 Regulates Schwann Cell Motility by its Effects of the GTPases, Rac1 and Rho

open access: yes, 2009
Low-density lipoprotein receptor-related protein (LRP-1) functions in endocytosis and in cell signaling directly (binding signaling adapter proteins) or indirectly (by regulating levels of other cell signaling receptors). In the peripheral nervous system
Jo M   +3 more
core  

Structural Covariance Analysis of Altered Brain Development in Neonates With Congenital Heart Disease After Surgery

open access: yesJournal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Brain development is altered in neonates with congenital heart disease (CHD), with well‐characterised reductions in regional brain volumes and enlargement of CSF spaces. However, perioperative morphological changes remain incompletely understood. Purpose To identify brain regions showing spatial patterns of coordinated expansion and
Mirthe E. M. van der Meijden   +14 more
wiley   +1 more source

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