Results 61 to 70 of about 10,096 (293)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Les circonscriptions ecclésiastiques intra-diocésaines : cartographie et territoire de l’époque médiévale à nos jours - Introduction

L'Atelier du CRH
This dossier explores intra-diocesan districts that although historiographically underrepresented, contributed significantly to the structuring of dioceses as intermediate levels whose interface status deserves to be examined to shed light both on Church
Stéphane Gomis, Vincent Flauraud
doaj   +1 more source

On Baptism and the Spirit: The Ethical Significance of the Marks of the Church [PDF]

, 1999
(Excerpt) As the church rounds the close of its second millennium, Christians must recapture the ecclesial and sacramental character of Christian ethics.
Guroian, Vigen
core   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Zombie multiculturalism meets liberative difference:Searching for a new discourse of diversity [PDF]

, 2017
This paper grapples with an unresolved tension – twenty-first century Britain is indelibly multicultural and yet diversity is increasingly depicted as a threat to social cohesion.
Alam Yusuf, Allen Chris, Baker Christopher R., Beckford Robert, Bhabha Homi, Cantle Ted, Cantle Ted, Chris Shannahan, Crawley Heaven, Ford Rob, Fryer Peter, Gilroy Paul, Gilroy Paul, Gilroy Paul, Girard René, Gutiérrez Gustavo, Hall Stuart, Harris Nigel, Jivraj Stephen, Kant Immanuel, Meer Nasar, Modood Tariq, Office for National Statistics, Parekh Bhiku, Phillips Trevor, Said Edward, Sandercock Leonie, Schreiter Robert, Sen Amartya, Shannahan Chris, Shannahan Chris, Simpson Ludi, Slater John, Tamez Elsa, Taylor Charles, West Cornel, West Cornel, Young Iris Marion   +37 more
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

African biblical hermeneutics on the threshold? Appraisal and wayforward

Acta Theologica, 2016
What appears to be African Biblical Hermeneutics often refers to the geographical location of the authors rather than the content. There always appears to be something new on the horizon, but the colonial umbilical cord prevents a crossing of the ...
M. Speckman
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source