Results 71 to 80 of about 323,461 (284)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Transformation of metal-organic frameworks for molecular sieving membranes
Nature Communications, 2016 Metal-organic frameworks (MOFs) are attracting increasing attention as membrane components for molecular sieving due to the range of desirable properties they exhibit.
Wanbin Li +10 more
doaj +1 more source
Advanced Energy & Sustainability Research, 2022 Enhancing crystal symmetry is perceived as the most efficacious strategy to improve the thermoelectric performance of GeSe. Although multicomponent alloying is commonly employed to increase crystal symmetry, the excessive point defects inevitably degrade
Bingcai Duan +8 more
doaj +1 more source
Probing Binding Interactions of Cytisine Derivatives to the α4β2 Nicotinic Acetylcholine Receptor [PDF]
, 2019 Nicotinic acetylcholine receptors (nAChRs) are crucial for communication between synapses in the central nervous system. As such, they are also implicated in several neuropsychiatric and addictive diseases.
Blom, Annet E. M. +4 more
core +4 more sources
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Results in Physics, 2018 Thin films of In2O3 and In2O3 doped with Ag+ or Cu2+ were assembled by spray pyrolysis from aqueous solution at 450 °C. The microstructure analysis and optical properties were investigated using XRD, SEM, EDX and UV–Vis. spectrophotometer.
Nasser Y. Mostafa +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Crystal structures of five 1-alkyl-4-aryl-1,2,4-triazol-1-ium halide salts
Acta Crystallographica Section E: Crystallographic Communications, 2015 The asymmetric units for the salts 4-(4-fluorophenyl)-1-isopropyl-1,2,4-triazol-1-ium iodide, C11H13FN3+·I−, (1), 1-isopropyl-4-(4-methylphenyl)-1,2,4-triazol-1-ium iodide, C12H16N3+·I−, (2), 1-isopropyl-4-phenyl-1,2,4-triazol-1-ium iodide, C11H14N3+·I−,
Marites A. Guino-o +5 more
doaj +1 more source