Results 51 to 60 of about 2,418,628 (260)

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Chronic copper poisoning in beef cattle in the state of Mato Grosso, Brazil [PDF]

Pesquisa Veterinária Brasileira, 2020
: Copper is an essential micromineral in animal feed; however, when consumed in excess, it can cause liver necrosis, hemolytic crisis, hemoglobinuric nephrosis and death in cattle. Although uncommon in this species, copper poisoning occurs as a result of
Kamila P.F. Martins, Vitor H.T. Padilha, Tércio K. Damasceno, Marcos A. Souza, Emanoelly M.S. Silva, Marlon Ribeiro, Asheley H.B. Pereira, Edson M. Colodel   +7 more
doaj   +1 more source

High prevalence of bovine tuberculosis in dairy cattle in central Ethiopia : implications for the dairy industry and public health [PDF]

, 2012
BACKGROUND: Ethiopia has the largest cattle population in Africa. The vast majority of the national herd is of indigenous zebu cattle maintained in rural areas under extensive husbandry systems.
Aseffa, A., Martin Vordermeier, Elena Hailu (108949), Rea Tschopp, Lawrence Yamuah, Sahile, M., Teklu Kiros (108956), Stephen V Gordon, Young, D., Stephen V. Gordon (108974), Abraham Aseffa (108981), Tschopp, R., Vordermeier, M., Lawrence Yamuah (108959), Hewinson, R. G., Elena Hailu, Gordon, S. V., Rebuma Firdessa (108932), Rea Tschopp (108939), Mesfin Sahile, Firdessa, R., Douglas Young, Stefan Berg (108985), Girume Erenso, Girume Erenso (108952), Hailu, E., Martin Vordermeier (108962), Kiros, T., Wubete, A., R. Glyn Hewinson (108965), Douglas Young (108969), Rebuma Firdessa, Alehegne Wubete (108943), Melaku Sombo (108946), Berg, S., Yamuah, L., Alehegne Wubete, Stefan Berg, Sombo, M., Erenso, G., Abraham Aseffa, Melaku Sombo, Teklu Kiros, R Glyn Hewinson, Mesfin Sahile (108978)   +44 more
core   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

The effect of pegbovigrastim administration on the nonspecific immunity of calves

Journal of Veterinary Internal Medicine
Background Prevention of diseases in the early rearing of calves is important, particularly because disease occurrence most often requires antimicrobial administration but reduction of their use in animals is a priority.
Katarzyna Dudek, Ewelina Szacawa, Dariusz Bednarek   +2 more
doaj   +1 more source

Herd-level risk factors associated with the presence of Phage type 21/28 E. coli O157 on Scottish cattle farms [PDF]

, 2006
<p>Background: E. coli O157 is a bacterial pathogen that is shed by cattle and can cause severe disease in humans. Phage type (PT) 21/28 is a subtype of E.
Fenlon, D, Allison Lesley, Low, JC, Chase-Topping Margo E, Chase-Topping, ME, Halliday Jo EB, Woolhouse Mark EJ, Pearce, Michael C., Chase-Topping, M.E., Low, C., McKendrick, IJ, Low, Christopher, Low, C, Pearce, M.C., Fenlon, D., Mellor, Dominic J., Halliday, JEB, Chase-Topping, M, Mellor Dominic J, Allison, L., Gunn, G.J., Gunn, GJ, McKendrick, Iain J., Pearce, MC; id_orcid, Fenlon Dave, McKendrick Iain J, Chase-Topping, Margo E., Gunn George J, Halliday, Jo E. B., Pearce, MC, Woolhouse, MEJ, McKendrick, I.J, Mellor, DJ, Pearce Michael C, Halliday, J.E.B., Allison, L, Allison, Lesley, Woolhouse, M.E.J., Mellor, D.J., Low Chris, Gunn, George J., Fenlon, Dave, Woolhouse, Mark E. J.; id_orcid   +42 more
core   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Construction of networks with intrinsic temporal structure from UK cattle movement data [PDF]

, 2008
Background: The implementation of national systems for recording the movements of cattle between agricultural holdings in the UK has enabled the development and parameterisation of network-based models for disease spread. These data can be used to form a
Webb, Cerian R., Vernon, Matthew C., Matthew C Vernon, Heath, M. Fred, M Fred Heath, Cerian R Webb, Vernon Matthew C, Heath M Fred, Webb Cerian R   +8 more
core   +3 more sources

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Cattle Disease Studies Via Geographical Information System in Bowi Subur Village, Masni District, Manokwari Regency, West Papua Province

Jurnal Ilmu-Ilmu Peternakan, 2023
Geographical Information System (GIS) and remote sensing provide real-time data to stakeholders. GIS is new and modern tool that are essential for mapping, monitoring, and surveillance of animal diseases.
Ni Putu Vidia Tiara Timur, Bangkit Luthfiaji Syaefullah, Susan Carolina Labatar, Ebit Eko Bachtiar   +3 more
doaj   +1 more source