Results 121 to 130 of about 550,647 (331)
PET Studies of Cerebral Levodopa Metabolism: A Review of Clinical Findings and Modeling Approaches [PDF]
, 2009 [18F]Fluoro-3,4-dihydroxyphenyl-l-alanine (FDOPA) was one of the first successful tracers for molecular imaging by positron emission tomography (PET), and has proven immensely valuable for studies of Parkinson’s disease.
Cumming, Paul, Kumakura, Yoshitaka
core +1 more source
Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments
Med Research, EarlyView.ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li +13 more
wiley +1 more source
A core eating network and its modulations underlie diverse eating phenomena [PDF]
, 2016 We propose that a core eating network and its modulations account for much of what is currently known about the neural activity underlying a wide range of eating phenomena in humans (excluding homeostasis and related phenomena).
Barsalou, Lawrence W. +2 more
core +1 more source
Brain Imaging Phenotypes Associated with Polygenic Risk for Essential Tremor
Movement Disorders, EarlyView.Abstract Essential tremor (ET) is a common movement disorder with a strong genetic basis. Magnetic resonance imaging (MRI), particularly diffusion‐weighted MRI (dMRI) and T1 MRI, have been used to identify brain abnormalities of ET patients. However, the mechanisms by which genetic risk affects the brain to render individuals vulnerable to ET remain ...
Miranda Medeiros +14 more
wiley +1 more source
The neurological underpinnings of cluttering: Some initial findings [PDF]
, 2015 Background Cluttering is a fluency disorder characterised by overly rapid or jerky speech patterns that compromise intelligibility. The neural correlates of cluttering are unknown but theoretical accounts implicate the basal ganglia and medial ...
Bretherton-Furness, Jess +4 more
core +1 more source
Neurodegenerative and Neurodevelopmental Roles for Bulk Lipid Transporters VPS13A and BLTP2
Movement Disorders, EarlyView.Abstract Background Bridge‐like lipid transfer proteins (BLTPs) mediate bulk lipid transport at membrane contact sites. Mutations in BLTPs are linked to both early‐onset neurodevelopmental and later‐onset neurodegenerative diseases, including movement disorders.
Sarah D. Neuman +4 more
wiley +1 more source
The novel MAPT mutation K298E:mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons [PDF]
, 2013 Frontotemporal lobar degeneration (FTLD) consists of a group of neurodegenerative diseases characterized by behavioural and executive impairment, language disorders and motor dysfunction.
Calo, Laura +11 more
core +3 more sources
Movement Disorders, EarlyView.Abstract Background Glial cell line–derived neurotrophic factor (GDNF) is required for development and survival of dopaminergic neurons. A previous trial evaluating lower‐dose adeno‐associated virus serotype 2–GDNF (AAV2‐GDNF) bilateral intraputaminal infusion in participants with advanced Parkinson's disease (PD) achieved 26% mean putaminal coverage ...
Amber D. Van Laar +10 more
wiley +1 more source
Severe apathy due to injury of prefronto-caudate tract
Translational Neuroscience, 2019 The caudate nucleus, which is vulnerable to hypoxic–ischemic brain injury (HI-BI), is important to cognitive function because it is connected to the prefrontal cortex. Using diffusion tensor tractography (DTT), no study on injury of the prefronto-caudate
Ho Jang Sung, Gyu Kwon Hyeok
doaj +1 more source
Неврология, нейропсихиатрия, психосоматика, 2019 Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease and the first one among the nosological entities of parkinsonism.
A. G. Trufanov +5 more
doaj +1 more source