Results 201 to 210 of about 53,163 (291)
Non‐Invasive, High‐Resolution (1H2O) Metabolic Activity Diffusion Imaging [MADI] of Rat Glioma
We employed Metabolic Activity Diffusion Imaging [MADI] and 18FDG‐PET in rats with syngeneic RG2 glioblastoma brain tumors. MADI quantifies kio (the cellular H2O efflux rate constant), cell volume (V), and cell density (ρ), without the use of contrast agents. The kioV product quantifies the rate of water efflux per cell.
Joshua W. Schlegel +9 more
wiley +1 more source
We analyzed the behavior of GPR143 gene‐deficient mice. GPR143‐KO mice displayed a mixed psychiatric phenotype. GPR143 may play a role in mesolimbic and mesocortical functions underlying sensory gating, reward, social hierarchy, cognition, and emotional regulation. ABSTRACT GPR143, originally identified as the gene product of ocular albinism 1 (OA1), a
Yoshio Goshima +9 more
wiley +1 more source
Volume reduction of caudate nucleus is associated with movement coordination deficits in patients with hippocampal atrophy due to perinatal hypoxia-ischaemia. [PDF]
Geva S +5 more
europepmc +1 more source
Abstract Background Valbenazine is used to treat dyskinesia and is generally associated with limited side effects; however, a few cases with the adverse effect of parkinsonism are reported in the literature. In this study, we report a case of valbenazine‐induced acute parkinsonism.
Yasuhito Nagai +2 more
wiley +1 more source
Post mortem MRI was combined with neuropathological assessments at 600 μm intervals throughout the brain. Through this approach, a three dimensional account of an entire human brain with an intermediate Alzheimer's disease neuropathologic change was created.
Anneke Alkemade +13 more
wiley +1 more source
Abstract INTRODUCTION Most Alzheimer's disease (AD) risk variants identified by genome‐wide association studies (GWAS) reside in noncoding regions, complicating causal interpretation. METHODS We developed PRISM‐xQTL (Pleiotropic Relationships Integrated with System‐level Multiomic QTL), integrating pleiotropy, co‐localization, Mendelian randomization ...
Nitesh Enduru, Zhongming Zhao
wiley +1 more source
Executive Impairment in Huntington's Disease: Insights From a Systematic Review of the Literature
Executive dysfunction in Huntington's disease follows a selective, stage‐dependent pattern, with early deficits in psychomotor speed, cognitive flexibility, inhibition, and working‐memory updating. Progression is associated with broader impairments in planning and attention.
Simone Migliore +4 more
wiley +1 more source
This study developed an integrated nomogram combining QSM‐based radiomics, brain iron deposition, white matter hyperintensity, and clinical markers. This model demonstrated superior performance in stratifying hypertensive cognitive impairment compared to traditional single‐parameter models.
Yu Su +12 more
wiley +1 more source

