Results 21 to 30 of about 44,410 (265)
REFINING THE MATERIAL SUBSTANCE: ARISTOTLE’S PROGRAM IN METAPHYSICS H1-5
Síntesis. Revista de Filosofía, 2018 En Metaph. Z17, Aristóteles toma un nuevo punto de partida (1041a6) en su discusión sobre la sustancia: la forma sustancial es principio y causa (1041a6-10, 1041b8), mientras que la materia es un elemento (1041b31) de las sustancias materiales. Además,
Fabián Mié
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Studium: Filosofía y Teología, 2014 El problema de Dios no ha sido considerado de una manera unívoca a través del tiempo. En esta reflexión no sólo han variado las respuestas, sino también los planteos del problema, cuyo objeto –Dios– es en sí mismo problemático, ya que no es objeto de ...
Dulce María Santiago
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
PlateletsImmune checkpoint inhibitors (ICIs) have transformed the treatment landscape for various malignancies, but they are associated with a range of immunerelated adverse events, including rare hematological complications.
Adolfo Fernández-Sánchez +6 more
doaj +1 more source
¿Causa eficiente o causa final?
Studium Veritatis, 2014 La atención siempre creciente por parte de la crítica y, en particular, de estudiosos que a nivel internacional se ocupan de la obra metafísica del teólogo granadino Francisco Suárez, ha hecho que se profundicen diversas temáticas contenidas en ella. Esto se debe, en especial, por la importante función que esa ha tenido, y todavía tiene, de mantener ...
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Haematologica, 2017 Immunoparesis or suppression of polyclonal immunoglobulins is a very common condition in newly diagnosed myeloma patients. However, the recovery of polyclonal immunoglobulins in the setting of immune reconstitution after autologous stem cell ...
Verónica González-Calle +18 more
doaj +1 more source