Results 81 to 90 of about 2,789,508 (310)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Tipos de MDO en los verbos psicológicos del español

Borealis: An International Journal of Hispanic Linguistics, 2015
RESUMEN. En el presente artículo se pretende argumentar la necesidad de establecer una distinción entre diferentes instancias de Marcado Diferencial de Objeto (MDO) en los verbos psicológicos de sujeto experimentante en español.
Bárbara Marqueta Gracia
doaj   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Implicaciones filosóficas de la eficiencia gerencial

Revista Visión Gerencial, 2009
Este ensayo da respuesta a varias de las preguntas que se plantean los seres humanos sobre la eficiencia. Para esto, propone una definición de términos permitiendo que el lector sepa a cual de los tantos conceptos se está refiriendo el autor ...
Rafael Alexis Acevedo Rueda
doaj  

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

EL NON BIS IN ÍDEM COMO FÓRMULA DEL PRINCIPIO DE LEGALIDAD QUE PERMITE EL INGRESO DEL ESTATUTO DE ROMA AL DERECHO INTERNO

Prolegómenos, 2009
El siguiente artículo tiene por objeto analizar una de las primeras consecuencias que se presentan en virtud de la adopción del Estatuto de Roma de 1998 para la adopción de la Corte Penal Internacional, en concreto desde los efectos que se desarrollan ...
Jaime Alberto Sandoval Mesa
doaj  

Transtorns cardíacs en el weaning [PDF]

, 2013
El fracàs del weaning té implicacions pronòstiques importants. Part de la recerca es centra en identificar factors predictors del weaning. La causa cardíaca està infradiagnosticada però actualment amb l'ús de l'ecocardiografia al serveis de medicina ...
Pedrós Mas, Cristina, Universitat Autònoma de Barcelona. Departament de Medicina, Universitat Autònoma de Barcelona. Facultat de Medicina   +2 more
core  

Study of Magnetic Properties of A_2B^'NbO_6 (A=Ba,Sr, (BaSr): and B^'=Fe and Mn) double perovskites

, 2004
We have studied the magnetic properties of Ba_2FeNbO_6 and Ba_2MnNbO_6. it is seen that Ba_2FeNbO_6 is an antiferromagnet with a weak ferromagnetic behaviour at 5K while Ba_2MnNbO_6 shows two magnetic transitions one at 45 K and the other at 12K ...
Attfield J. P., Blasse G., Causa M. T., Eng Hank W., Gerriitsen H. J., J. B. Philipp, K. Chandrasekaran, M. Opel, M. S. Ramachandra Rao, N. Rama, R. Gross, V. Sankaranarayanan   +11 more
core   +1 more source

Sex Differences in Medication Discontinuation in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Objective We examined sex differences in medication discontinuation among patients with axial spondyloarthritis (axSpA) initiating tumor necrosis factor inhibitors (TNFi), interleukin‐17 inhibitors (IL‐17i), or JAK inhibitors (JAKi). Methods Using data from the Rheumatology Informatics System for Effectiveness (RISE) Registry (2003–2025), we assessed ...
Rachael Stovall, Cinthia Blat, Eric Roberts, Jean W. Liew, Katherine Wysham, Namrata Singh, Janna Friedly, Lianne S. Gensler, Gabriela Schmajuk, Jinoos Yazdany   +9 more
wiley   +1 more source