Results 71 to 80 of about 25,577 (238)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The Causal Efficacy of Consciousness

Entropy, 2020
Mental causation is vitally important to the integrated information theory (IIT), which says consciousness exists since it is causally efficacious.
Matthew Owen
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Causal Closure Argument is No Threat to Non-Reductive Physicalism

Humana.Mente: Journal of Philosophical Studies, 2015
Non-reductive physicalism is the view that mental events cause other events in virtue of their mental properties and that mental properties supervene on, without being identical to, physical properties.
Peter Menzies
doaj  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Zero Tier Execution Substrate for Evolutionary Software Systems

Systems
Adaptive and evolutive software systems are characterized by ontologically defined non-determinism—not a defect but the primary force of their evolution.
Aleksandar Ivanović, Miloš Radenković, Sergei Prokhorov, Aleksandra Labus, Božidar Radenković   +4 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Can Western Monotheism Avoid Substance Dualism?

Zygon, 2001
The problem of divine agency and action is analogous to the problem of human agency and action: How is such agency possible in the absence of a dualistic causal interaction between disparate orders of being?
doaj   +2 more sources

An exploratory study of voicing-related differences in vowel duration as compensatory temporal adjustment in Italian and Polish

Glossa, 2019
Over a century of phonetic research has established the cross-linguistic existence of the so called “voicing effect”, by which vowels tend to be shorter when followed by voiceless stops and longer when the following stop is voiced.
Stefano Coretta
doaj   +2 more sources