Results 161 to 170 of about 1,964,226 (308)

Causal Discovery in High-dimensional, Multicollinear Datasets. [PDF]

Front Epidemiol, 2022
Jia M, Yuan DY, Lovelace TC, Hu M, Benos PV.   +4 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A causal discovery-based adaptive fusion algorithm for multi-source heterogeneous knowledge graphs. [PDF]

Sci Rep
Wang T.
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

One-class edge classification through heterogeneous hypergraph for causal discovery. [PDF]

Sci Rep
Gôlo MPS, Marcacini RM.
europepmc   +1 more source

Causal discovery approach with reinforcement learning for risk factors of type II diabetes mellitus. [PDF]

BMC Bioinformatics, 2023
Gao XE, Hu JG, Chen B, Wang YM, Zhou SB.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Post-selection inference for causal effects after causal discovery. [PDF]

Biometrika
Chang TH, Guo Z, Malinsky D.
europepmc   +1 more source

Generalism drives abundance: A computational causal discovery approach. [PDF]

PLoS Comput Biol, 2022
Song C, Simmons BI, Fortin MJ, Gonzalez A.   +3 more
europepmc   +1 more source

Causal discovery and logic [PDF]

, 2013
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