Results 41 to 50 of about 2,845 (293)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Measuring the alternation strength of causative verbs

, 2017
This paper presents a method for quantitative and qualitative analyses of the causative alternation in English, where verbs may alternate between a transitive (causative) construction (Santa crinkled his eyes) and ...
Laurence Romain
core   +1 more source

Alternating arguments of Polish psych verbs

Glossa
This paper focuses on the Experiencer Object (EO)/Experiencer Subject (ES) alternation in Polish. This alternation is viewed here as distinct from the causative/anticausative alternation, because eventive EO verbs do not pattern like change of state (COS)
Anna Bondaruk, Bozena Rozwadowska
doaj   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Causative alternation in Hong Kong sign language. [PDF]

, 2002
Sin Yee Prudence, Lau.Thesis (M.Phil.)--Chinese University of Hong Kong, 2002.Includes bibliographical references.Abstracts in English and Chinese.Chapter Chapter 1: --- Introduction PageChapter 1.1 --- Introduction --- p.1Chapter 1.1.1 --- Causativity ...

core  

Entre passif et anticausatif : étude des formes itCaCaC en arabe du Caire

Lidil, 2021
This study deals with the interpretations received by verbs formed on the t‑I pattern in Cairo Arabic, passive and anticausative interpretations. First, we note on the one hand that verbs of t‑I form characterized by an inherent transitivity receive only
Julie Haslé
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Transitivity Index: Using Transitivity as a continuous measure to account for clitic case alternation in Spanish causative constructions.

PLoS ONE, 2021
In Spanish causative constructions with dejar 'let' and hacer 'make' the subject of the embedded infinitive verb can appear in the accusative or the dative case.
Gustavo Guajardo
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source