Results 41 to 50 of about 12,022 (300)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Entre passif et anticausatif : étude des formes itCaCaC en arabe du Caire

Lidil, 2021
This study deals with the interpretations received by verbs formed on the t‑I pattern in Cairo Arabic, passive and anticausative interpretations. First, we note on the one hand that verbs of t‑I form characterized by an inherent transitivity receive only
Julie Haslé
doaj   +1 more source

Ro[u:]ting the interpretation of words [PDF]

, 2009
Word formation in Distributed Morphology (see Arad 2005, Marantz 2001, Embick 2008): 1. Language has atomic, non-decomposable, elements = roots. 2. Roots combine with the functional vocabulary and build larger elements. 3.
Alexiadou, Artemis
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The Transitivity Index: Using Transitivity as a continuous measure to account for clitic case alternation in Spanish causative constructions.

PLoS ONE, 2021
In Spanish causative constructions with dejar 'let' and hacer 'make' the subject of the embedded infinitive verb can appear in the accusative or the dative case.
Gustavo Guajardo
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Causative-ergative alternation in Brazilian Portuguese

Matraga, 2009
This paper is concerned with the conditions that govern variation in causative-ergative constructions in Brazilian Portuguese. Following research by Whitaker-Franchi (1989) and Levin & Rappaport-Hovav (1995), those conditions are reformulated based on ...
Larissa Ciríaco, Márcia Cançado
doaj  

Directionality in the psych alternation: a quantitative cross-linguistic study

Linguistic Typology
Languages display global preferences for transitive, intransitive or underspecified roots in their verbal lexicon and correspondingly for the use of processes for deriving related concepts with different valency (cf. Nichols, Johanna, David A. Peterson &
Rott Julian Andrej, Verhoeven Elisabeth, Fritz-Huechante Paola   +2 more
doaj   +1 more source

Optimizing the feeding frequency to maximize the production of sterile males in tsetse mass-rearing colonies.

PLoS ONE, 2021
Tsetse flies are cyclical vectors of trypanosomes, the causative agents of sleeping sickness or Human African Trypanosomosis and nagana or African Animal Trypanosomosis in Sub-Saharan Africa.
Soumaïla Pagabeleguem, Ange Irénée Toé, Sié Hermann Pooda, Kiswendsida Mikhailou Dera, Abdou Salam Belem, Adrien Marie Gaston Belem, Gisèle Marie Sophie Ouedraogo/Sanou, Mamadou Ira, Bénéwendé Aristide Kaboré, Lassané Percoma, Issa Sidibé   +10 more
doaj   +1 more source

The semantics of the native greek verb suffixes / Chariton Charitonidis [PDF]

, 2011
The aim of this paper is to give the semantic profile of the Greek verb-deriving suffixes -íz(o), -én(o), -év(o), -ón(o), -(i)áz(o), and -ín(o), with a special account of the ending -áo/-ó.
Charitōnidēs, Charitōn Ch.
core