Results 71 to 80 of about 558,486 (265)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Development and application of a risk analysis methodology for road traffic accidents

Alexandria Engineering Journal
Collision, rollover, swerving, and vehicle fire are road traffic accidents (RTAs) caused by driver, vehicle, and environment-related factors, resulting in diverse severity levels, such as property damages, injuries, and fatality.
Radfan Abdulrahman, Meshal Almoshaogeh, Husnain Haider, Fawaz Alharbi, Arshad Jamal   +4 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Analysis of the Causes and the Consequences of Consecutive RMB Appreciation

Journal of Financial Risk Management, 2014
Since the reform and opening-up, China’s foreign trade has obtained at breakneck speed, and in the international competition accumulated the massive trade surplus and foreign exchange reserves. That makes some western countries claim that the value of RMB was severely underestimated, which brought about unprecedented and consecutive appreciation ...
Shuixiang Luo, Yue Zhang, Meilin Hu, Yuhong Li   +3 more
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Climate change: An analysis of causes and consequences

International Journal of Geography, Geology and Environment, 2023
Krishn Pal Singh, Dr. Anuj Kumar
openaire   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Consequence Analysis of fire and explosion of a cylindrical LPG tank in a selected industry of oil and gas

Salāmat-i kār-i Īrān, 2017
Background and aims: Accidents happened as a result of LPG leakage emphasizes the importance of the consequence analysis of fire and explosion in LPG storage tanks.
Hamid Kariznovi, Ali Asghar Farshad, Rasoul Yarahmadi, Yahya Khosravi, Peyman Yari   +4 more
doaj  

Determination of Road Functionality for Küçükçekmece District Following a Scenario Earthquake for Istanbul

International Journal of Environment and Geoinformatics, 2016
Istanbul has been affected by earthquakes throughout its history. The most recent earthquake to shake Istanbul was on August 17 1999, along the North Anatolian Fault, 12 km southeast of the Izmit Province, with a magnitude of 7.4.
Betül Ergün Konukcu, Himmet Karaman, Muhammed Şahin   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source