Results 201 to 210 of about 2,059,704 (313)

Death rates due to suicide and homicide among persons aged 10\u201324 : United States, 2000\u20132017

Key findingsData from the National Vital Statistics System\u2022 After stable trends from 2000 to 2007, suicide rates for persons aged 10\u201324 increased from 2007 (6.8 per 100,000 persons) to 2017 (10.6), while homicide rates declined from 2007 to ...

core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Cause of death diversity in multi-group settings: an application to Latin America and the Caribbean. [PDF]

Popul Health Metr
Calazans JA, Permanyer I.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

National and provincial burden of interstitial lung disease mortality in China, 2013-2021: a nationwide analysis of trends and underlying cause of death. [PDF]

Respir Res
Yan F, Yu L, Zhou Z, Wang L, Zhou M, Zhang Z, Yin P.   +6 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Mechanical traumatic injuries as a cause of death in free-ranging neotropical non-human primates living in anthropogenic matrices. [PDF]

Primates
Barros RM, de Macêdo IL, de Sousa DER, da Fonseca YNG, de Albuquerque Cerqueira L, de Toledo Costa GR, Hirano LQL, de Castro MB.   +7 more
europepmc   +1 more source

Prescription drug overdose data & statistics guide : multiple causes of death (MCOD) dataset

CDC WONDER\u2014Wide-ranging Online Data for Epidemiologic Research\u2014is an integrated, user-friendly, menu-driven data system that provides public-use data sets about mortality (deaths), cancer incidence, HIV and AIDS, tuberculosis, vaccinations ...

core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source