Results 271 to 280 of about 4,353,386 (346)

Evaluating the performance of verbal autopsy for assigning cause of death in older adults: A population-based cohort study in Karonga, Malawi. [PDF]

Trop Med Int Health
Marston M, Chung A, Dube A, McLean E, Clark S, Crampin A, Calvert C.   +6 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Ultrasound imaging identifies the antemortem and postmortem features: PMI in euthanized dogs with an implication of cause of death may mask the imaging findings. [PDF]

Open Vet J
Eleid M, Elalfy M, Meligy AMA, Fehaid A, Elmadawy MA, Mohamad ZAA, Alkhodair KM, Elnahas A.   +7 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Beyond the underlying cause of death: an algorithm to study multi-morbidity at death. [PDF]

Popul Health Metr
Grippo F, Frova L, Pappagallo M, Barbieri M, Trias-Llimós S, Egidi V, Meslé F, Désesquelles A.   +7 more
europepmc   +1 more source

Using α-mangostin from Garcinia mangostana to block cell death caused by Paclitaxel in proliferating BHK cells

, 2017
Andrea Wojciechowski
openalex   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Capillary leak phenotype as a major cause of death in patients with POEMS syndrome. [PDF]

Leukemia
Lee K, Kourelis T, Tschautscher M, Warsame R, Buadi F, Gertz M, Muchtar E, Dingli D, Hayman S, Go R, Hwa L, Fonder A, Gonsalves W, Hobbs M, Kyle R, Kapoor P, Leung N, Binder M, Cook J, Lin Y, Rogers M, Rajkumar SV, Kumar S, Dispenzieri A.   +23 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source