Results 281 to 290 of about 5,086,231 (350)

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

Mortality Rate and Cause of Death in Adults with Extrapulmonary Nontuberculous Mycobacteria Infection, Denmark. [PDF]

Emerg Infect Dis
Pedersen AA, Dahl VN, Løkke A, Holden IK, Fløe A, Ibsen R, Hilberg O, Johansen IS.   +7 more
europepmc   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Starvation remains the leading cause of death in Tigray, northern Ethiopia, after the Pretoria deal: a call for expedited action. [PDF]

BMC Public Health
Haileselassie M, Kahsay H, Teklemariam T, Gebretsadik A, Gessesse A, Desta AA, Kebede H, Mamo N, Negash D, Bahresilassie M, Esayas R, Haile A, Gebreegziabiher G, Kahsay A, Gebregergs GB, Amare H, Mulugeta A.   +16 more
europepmc   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

[Cause of death statistics-how to avoid misinterpretation of mortality data]. [PDF]

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
Stolpe S, Kowall B.
europepmc   +1 more source

The Long Term Effects of a 12‐Session Community Exercise Program on Health Measures in Cancer Patients

Aging and Cancer, EarlyView.
ABSTRACT Purpose To assess the long‐term effects of a community cancer exercise program on quality of life, fatigue, weight, waist circumference, physical activity levels, lower extremity strength, body mass index (BMI), heart rate, and blood pressure, across non‐metastatic and metastatic patients.
Isaac Oppong, Roozbeh Naemi
wiley   +1 more source

A single exposure to brivaracetam or perampanel does not cause cell death in neonatal rats. [PDF]

Front Pediatr
Witherspoon E, Zuczek N, Williams G, Bernstein B, Ghosh A, Culjat M, Kaushal S, Forcelli PA.   +7 more
europepmc   +1 more source

Evaluation of dosimetric and spatial accuracy of a virtual cone technique for radiosurgery using linac‐integrated CBCT‐based polymer gel dosimetry

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose This study evaluates the dosimetric and geometric precision of a virtual cone technique using CBCT‐based polymer gel dosimetry, enabling radiation delivery, and imaging readout within an identical spatial coordinate system. Methods We created a C# script for a virtual cone technique that generates a treatment plan with 10 gantry arcs ...
Tenzin Kunkyab, Michael Lamey, Andrew Jirasek, Michael Kudla, Nathan Becker, Benjamin Mou, Derek Hyde   +6 more
wiley   +1 more source

Mortality associated with osteoporosis and pathological fractures in the United States (1999-2020): a multiple-cause-of-death study. [PDF]

J Orthop Surg Res
Huo R, Wei C, Huang X, Yang Y, Huo X, Meng D, Huang R, Huang Y, Zhu X, Yang Y, Lin J.   +10 more
europepmc   +1 more source