Results 111 to 120 of about 5,176,576 (252)
International audienceCauses-of-death (CoD) statistics are based on an analysis of the texts written by medical practitioners on death certificates, which are then classified and coded according to the World Health Organization's International ...
Coudin, Elise, Robert, Aude
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Causes of Corruption: Evidence from China [PDF]
In this study we explore in detail the causes of corruption in China using two different sets of data at the regional level (provinces and cities). We observe that regions with more anti-corruption efforts, histories of British rule, higher openness ...
Bin Dong, Benno Torgler
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
A Re-examination of Causes of Deforestation and Environmental Kuznets Curve: Evidences from Latin America, Africa and Asia [PDF]
Previous cross-country regression analyses on the causes of deforestation seem to have misspecified the regression models, in which the causes at different levels are mixed, leading to flawed cause-effect relationship between the rate of deforestation ...
Dutta, Dilip, Culas, Richard
core
Parents' beliefs on the causes of child maltreatment [PDF]
, 2013 The present study presents an analysis of the beliefs of a sample of Portuguese parents on the causes of child maltreatment as well as an analysis of the variability factors of such beliefs.
Calheiros, M. M.
core
Planning to reduce childhood blindness in India
Indian Journal of Ophthalmology, 1998 Reduction of blindness in children assumes particular significance since a blind child suffers from more blind-years than a blind adult. Estimates of the number of children blind in India and the causes of blindness are relatively crude as there are ...
Dandona Lalit +3 more
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source