Results 221 to 230 of about 5,176,576 (252)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Tackling Waste of Fruits and Vegetables in Chilean Households with Tailored Informational-Enablement Interventions: A Randomized Controlled Pilot Study. [PDF]

Foods
Fredes C, Benavente MI, Rudolph F, Méndez G, Rojas L, Pérez MI, Avello D, Fernández-Verdejo R, Echeverría F.   +8 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The impact of a brief psychoeducational intervention on hospital security personnel's attitudes towards aggression and violence management at Cecilia Makiwane Hospital. [PDF]

S Afr J Psychiatr
Mncinci I, Thungana Y.
europepmc   +1 more source

Determining causes of death through an abridged verbal autopsy tool: a pilot test conducted among vulnerable communities in Kolkata, India. [PDF]

BMJ Glob Health
Kanungo S, Lewis MG, Barman D, Bhunia PK, Chatterjee S, Samanta S, Yadav D, Pati S, Talukdar R, Chakraborty S, Das I, Chattopadhyaya A, Ghosh S, Datta K, Kalter HD, Guha-Sapir D.   +15 more
europepmc   +1 more source

Causes of death and mortality patterns in clozapine-treated patients: 17-year retrospective cohort study. [PDF]

BJPsych Open
Alonso-Garcia M, Seabright D, Achakzai GM, Ali A, Krishnadas R, Cardinal RN, Jenkins C, Arango C, Fernandez-Egea E.   +8 more
europepmc   +1 more source

Rapid-Onset Amoxicillin-Clavulanate Liver Injury Requires Stronger Exclusion of Alternative Causes and Fuller Causality Reporting in Atypical DILI Case Reports. [PDF]

Clin Case Rep
Awan MA, Raza HU.
europepmc   +1 more source