Results 101 to 110 of about 167,241,951 (289)

Natural, unnatural, and cause-specific mortality among current psychiatric inpatients: a systematic review and meta-analysisResearch in context

EClinicalMedicine
Summary: Background: Mortality in psychiatric hospitals is both elevated and poorly understood. We aimed to address a knowledge gap about cause-specific mortality among current psychiatric inpatients using a meta-analytic synthesis of primary research ...
Helena Angel-Scott, Ashna Basu, Allyson Tai, Pramudie Gunaratne, Patrick Bolton, Jackie Curtis, Grant Sara, Matthew Large   +7 more
doaj   +1 more source

Hospital-Based Mortality in Federal Capital Territory Hospitals-Nigeria, 2005- 2008

The Pan African Medical Journal, 2012
BACKGROUND: Cause-specific mortality data are important to monitor trends in mortality over time. Medical records provide reliable documentation of the causes of deaths occurring in hospitals.
Nykiconia Preacely, Oladayo Biya, Saheed Gidado, Halima Ayanleke, Mohammed Kida, Moses Akhimien, Aisha Abubakar, Ibrahim Kurmi, Ikeoluwapo Ajayi, Patrick Nguku, Henry Akpan   +10 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The Cause of Death [PDF]

Journal of the Royal Society of Medicine, 1986
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The amount of overlap causes of death in developing countries in PubMed and Scopus databases

مدیریت اطلاعات سلامت, 2015
Introduction: The Primary Goal of Physicians are salvation of the human life. Physicians can research through medical databases in causes of death, are closer to this goal.
Zahra Khajeali Jahantighi, Tahereh Rigi, Maryam Rigi, Nazanin Sanadgol Nezami   +3 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Diabetes como causa básica ou associada de morte no Estado de São Paulo, Brazil, 1992

Revista de Saúde Pública
INTRODUÇÃO: As estatísticas de mortalidade, em geral, baseiam-se na análise das causas básicas de óbito. No caso do diabetes, sua importância é sempre subestimada, pois os diabéticos geralmente morrem devido às complicações crônicas da doença, sendo ...
Laercio J. Franco, Cecília Mameri, Heloisa Pagliaro, Lúcia C. Iochida, Paulete Goldenberg   +4 more
doaj