Results 121 to 130 of about 96,132 (296)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

High-Resolution Caustic Beam Shaping via Polarization Transformation Through Highly Anisotropic Scattering Media

Optics
Manipulating complex light fields through highly anisotropic scattering medium (HASM) remains a fundamental challenge due to the intricate underlying physics and broad application potential.
Yu-Han Zhou, Guang-Ze Li, Lu-Hong Zhang, Ning-Chen Cao, Li-Ming Zhu, Xiao-Bo Hu, Yan Wu, Khian-Hooi Chew, Rui-Pin Chen   +8 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Malmquist-like Bias in the Inferred Areas of Diamond Caustics and Consequences for the Inferred Time Delays of Gravitationally Lensed Quasars

The Astrophysical Journal
Quasars are quadruply lensed only when they lie within the diamond caustic of a lensing galaxy. This precondition produces a Malmquist-like selection effect in observed populations of quadruply lensed quasars, overestimating the true caustic area.
Derek M. Baldwin, Paul L. Schechter
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Caustic ingestion

Annals of Emergency Medicine, 1983
R, Nelson, P, Walson, M, Kelley
openaire   +4 more sources

Effect of Wood Fillers on Strength and Biodegradation of Caustic Magnesite

BioResources
During their usage, caustic magnesite composites are susceptible to aggressive microbial action. This paper investigated the resistance of wood-filled caustic magnesite composites in a standard filamentous fungi medium. Caustic magnesite composites based
Vladimir Erofeev, Irina Stepina, Renat Badamshin, Victor Afonin, Vasily Smirnov, Svetlana Samchenko, Irina Kozlova   +6 more
doaj  

Edge diffracted caustic fields [PDF]

The fields near a caustic created by an edge diffraction process are computed using the equivalent current concept. These fields are shown to have the property commonly associated with ray optical analysis or the Geometrical Theory of Diffraction (GTD ...
Burnside, W. D., Peters, L., Jr.
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source