Results 151 to 160 of about 19,971 (265)

Acute Copper Toxicity: Succimer Makes you Less Blue. [PDF]

J Med Toxicol
Ivanov I, Abouelela W, Debbie T, Fernández D, Nelson LS, Mudan A.   +5 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Endoscopic incisional therapy for esophageal strictures in children: a retrospective cohort study. [PDF]

Surg Endosc
Rechtman OG, Slae M.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Benign gastric outlet obstruction: evolving strategies from surgery to endoscopic ultrasound-guided gastrojejunostomy. [PDF]

Ther Adv Gastrointest Endosc
Rizzo GEM, Infantino G, Rancatore G, Quintini D, Ligresti D, Belluardo N, Rizzo G, D'amore E, Giacchetto M, Tarantino I.   +9 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In the Soup: Caustic Ingestion from the Improper Consumption of a Self-Heating Soup

Western Journal of Emergency Medicine, 2012
John William Hafner, Matthew Hanson
doaj  

Tracing Corrosive Damage in Human Teeth: A Forensic Pilot Study of Household Agents Using Stereomicroscopy, SEM-EDX and Ground Sections. [PDF]

Molecules
Udriştioiu LA, Enăchescu M, Cârstea AE, Curcă GC, Popa MM, Andrei M.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Attitudes Towards Animals and Calf Disbudding Techniques: A Mixed Methods Study Using the Animal Attitude Scale (AAS-10). [PDF]

Vet Sci
Calix AD, Lamino P, Rodríguez-Mori H, Garcia A, Artemiou E.   +4 more
europepmc   +1 more source