Results 161 to 170 of about 63,569 (299)

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Microbial diversity in Pyrenean ice caves: extreme cryogenic environments as analogues for extraterrestrial habitability. [PDF]

FEMS Microbes
Muñoz-Hisado V, Puente-Sánchez F, Bartolomé M, Giménez R, Garcia-Lopez E, Moreno A, Cid C.   +6 more
europepmc   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Neotaphonomic characteristics of vertebrate site formation in underwater caves. [PDF]

PLoS One
Walker MM, Wilkinson JE, Stewart M, Jacobsen GE, Kumar S, Levchenko V, Fallon S, Esmay R, Wood R, Miszkiewicz JJ, Price GJ, Reed E, Monks J, Louys J.   +13 more
europepmc   +1 more source

Absorption of Broadband Low‐Frequency Sound Beyond the Thermodynamics Limit: An Acoustic Resonator With Magnetic Bearing

Advanced Science, EarlyView.
This work presents a magnetic‐bearing acoustic resonator that overcomes the thermodynamics limit of sound absorption. By introducing tunable negative stiffness, it achieves broadband low‐frequency absorption within a compact cavity, far exceeding the performance achievable by classic mass‐tuned designs.
Ying Hu, Zhe Zhang, Bohua Huang, Xue Han, Hallam Bastin Kilcoyne, Lixi Huang   +5 more
wiley   +1 more source

Numerical Simulation and Borehole Azimuthal Acoustic Imaging of Near-Borehole Caves in Formations with Axially Non-Uniform Wave Velocities. [PDF]

Sensors (Basel)
Yang B, Che X, Zhao T, Lu J, Men B, Qiao W.   +5 more
europepmc   +1 more source

Hollow Cu2O Nanozymes Enhance Probiotic Therapy for Colitis via Redox Homeostasis and TXNIP/NLRP3 Inflammasome Inhibition

Advanced Science, EarlyView.
Hollow cuprous oxide (H‐Cu2O) nanozymes feature enlarged catalytic surfaces for superior reactive oxygen species (ROS) scavenging. By efficiently neutralizing mucosal ROS, H‐Cu2O directly suppresses the TXNIP/NLRP3 inflammasome axis and restores intestinal epithelial barrier integrity.
Guangzhao Wang, Jialing Cao, Pengfei Li, Yujie Wang, Shiqi Lu, Kangliang Sheng, Shan Gao, Yongzhong Wang   +7 more
wiley   +1 more source

Pressure Transient Analysis of Fractured Caved Carbonate Condensate Gas Reservoirs with Laterally Beaded Large-Scale Caves. [PDF]

ACS Omega
Li D, Wan X, Zou N, Pan D, Lu Z.
europepmc   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Camera trapping survey of vertebrates in Lipis Geopark, Pahang, Malaysia with notes on cave utilisation by mainland clouded leopard (<i>Neofelis nebulosa</i>). [PDF]

Biodivers Data J
Azidi SNZ, Halmi NZ, Anak Chuat JC, Ahamed Noordeen SN, Mohd Yazid MH, Hasrizal Fuad MAB, Arifuddin MN, Mukri I, Har FP, Giordano AJ, Vijaya Kumaran J.   +10 more
europepmc   +1 more source