Results 191 to 200 of about 207,102 (284)

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

High-efficiency methane consumption by atmospheric methanotrophs in subsurface karst caves: The irrefutable methane sink. [PDF]

Sci Adv
Liu X, Cheng X, Zhang Y, Zhao R, Wang W, Li Y, Chen ZQ, Qiu X, Tuovinen OH, Bull ID, Evershed RP, Wang H.   +11 more
europepmc   +1 more source

2D Metal‐Organic Frameworks for High‐Performance Solid‐State Electrolytes: A Comprehensive Review

Advanced Science, EarlyView.
In this review, we elucidate the intrinsic advantages, synthetic methodologies, structural characteristics, ion‐transport mechanisms and performance optimization strategies while highlighting representative material systems and applications of 2D MOFs for electrolyte applications.
Changchun Ai, Yuan Tian, Yilei Shu, Peng Hang, Wentao Li, Yiling Yao, Huijuan Guo, Qun Yi, Hongmei Dai   +8 more
wiley   +1 more source

A glimpse into darkness: Diversity of culturable cyanobacteria, green algae and fungi from subaerial cave biofilms. [PDF]

J Phycol
Jung P, Briegel-Williams L, Nürnberg DJ, Wolf T, Guillen A, Leira M, Lakatos M.   +6 more
europepmc   +1 more source

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

List of Hard Ticks (Acari: Ixodida: Ixodidae) in Subterranean Habitats in Croatia. [PDF]

Pathogens
Krčmar S, Ozimec R.
europepmc   +1 more source

Cluster‐Mediated Solute Stabilization and Shear‐Bypass Synergistic Strengthening in High‐Alloyed Systems

Advanced Science, EarlyView.
This study demonstrates that in high‐alloy systems, nanoclusters with high solute tolerance can effectively suppress compositional segregation. This mitigation leads to a concurrent 18.7% increase in strength and 41.5% improvement in ductility, which is attributed to a shear‐bypass synergistic strengthening mechanism. The findings provide a new pathway
Wei Yu, Yu Bai, Jiawen Li, Kaixi Jiang, Hai Hao, Tao Jiang, Shunan Zhang, Yong Li, Zhaodong Wang, Kai Zhao, Shiwei Li   +10 more
wiley   +1 more source

Cave dogs around major urban areas of Arequipa, Peru, threaten rabies elimination program. [PDF]

Front Vet Sci
Castillo-Neyra R, Díaz EW, Bellotti BR, Morucci K, De la Puente-León M, Ortiz-Cam L, Levy MZ.   +6 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Subterranean Biodiversity on the Brink: Urgent Framework for Conserving the Densest Cave Region in South America. [PDF]

Animals (Basel)
Zampaulo RA, Souza-Silva M, Ferreira RL.
europepmc   +1 more source