Results 141 to 150 of about 104,865 (293)

CRISPR‐Based Gene Dependency Screens Reveal Mechanism of BRAF Inhibitor Resistance in Anaplastic Thyroid Cancer

open access: yesMolecular Carcinogenesis, EarlyView.
ABSTRACT Anaplastic thyroid cancer (ATC) is the most aggressive form of thyroid cancer. Despite recent advances in treating BRAFV600E‐driven ATC, therapy resistance remains a significant challenge, often resulting in disease progression and death.
Shawn Noronha   +26 more
wiley   +1 more source

Clinical Progression in Alpha‐Synuclein Positive LRRK2‐PD and Sporadic Parkinson's Disease: A Longitudinal Analysis

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background LRRK2‐Parkinson's disease (LRRK2‐PD) is biologically heterogeneous with approximately 30% lacking aggregated alpha synuclein (αSyn) in cerebrospinal fluid by seed amplification assay (SAA). Prior work has suggested slower progression in LRRK2‐PD compared to sporadic PD (sPD).
Lucy A. Morse   +224 more
wiley   +1 more source

Machine Learning Assisted Prediction of Degradation Behavior of Poly(Lactic‐Co‐Glycolic Acid)

open access: yesMaterials Genome Engineering Advances, EarlyView.
Using a gradient boosting‐based machine learning model trained on 484 data points, this study predicts the degradation behavior of poly(lactic‐co‐glycolic acid) (PLGA) implants. Degradation time, molecular weight, and lactide/glycolide ratio were identified as key governing factors, enabling accurate prediction while reducing reliance on extensive ...
Shuai Wang   +11 more
wiley   +1 more source

Open letter: Brazil at a crossroads—Protecting peatlands is essential for post‐COP30 climate leadership

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
This Open Letter highlights peatlands as critical yet overlooked ecosystems in Brazil's climate and biodiversity policies. By translating scientific evidence into clear, actionable priorities for policymakers, it supports more accurate climate reporting, effective mitigation strategies, and improved land‐use governance.
Suelma Ribeiro Silva   +52 more
wiley   +1 more source

From Theatre to Transformation: Learning, Action, and Diffusion for SDG2 in Cambodia

open access: yesSustainable Development, EarlyView.
ABSTRACT The arts are envisioned as able to help address the longstanding ‘implementation gap’ between research and realisation of the Sustainable Development Goals (SDGs). For SDG2 (Zero Hunger), Forum Theatre offers a participatory alternative to top‐down interventions, yet its impacts have not been evaluated using rigorous, mixed‐methods that are ...
Brian R. Cook   +6 more
wiley   +1 more source

A Hero's Journey to Systemic Change: Developing Expertise in Agricultural Development

open access: yesSustainable Development, EarlyView.
ABSTRACT Experts in rural development and agrarian change wield considerable influence over programme design and delivery, directing resources and shaping trajectories towards the Sustainable Development Goals (SDGs). Yet the pathways through which such expertise develops remain under‐examined. This study examines the journey to expertise among experts
Kirt Hainzer   +7 more
wiley   +1 more source

High‐Pressure Transformations and Stability of Ferromagnesite in the Earth's Mantle

open access: yesGeophysical Monograph Series, Page 105-113., 2020

This book is Open Access. A digital copy can be downloaded for free from Wiley Online Library.

Explores the behavior of carbon in minerals, melts, and fluids under extreme conditions

Carbon trapped in diamonds and carbonate-bearing rocks in subduction zones are examples of the continuing exchange of substantial carbon ...
Eglantine Boulard   +2 more
wiley  

+5 more sources

Can Environmental Markets Pay for More Sustainable Farm Dams? A Cost–Benefit Analysis

open access: yesSustainable Development, EarlyView.
ABSTRACT Farm dams are widespread artificial waterbodies that play a critical role in agricultural water security. Enhancing these systems through sustainable interventions such as fencing, hardened access points, and revegetation can improve water quality and deliver carbon and biodiversity co‐benefits.
K. U. D. N. Hansani   +4 more
wiley   +1 more source

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