Results 181 to 190 of about 103,123 (277)

ER degradation for ER⁺/HER2- advanced or metastatic breast cancer: a phase 1 trial. [PDF]

Nat Commun
Hamilton E, Layman RM, Cosgrove D, Danso M, Zhang H, He W, Kim SY, Fan J, Patel MR.   +8 more
europepmc   +1 more source

Olaparib for patients with tumors harboring alterations in homologous recombination repair genes: Results from the drug rediscovery protocol

International Journal of Cancer, Volume 158, Issue 6, Page 1617-1627, 15 March 2026.
What's new? PARP inhibitors are effective in patients with inactivating alterations in the BRCA1/2 genes across tumor types. However, the efficacy of PARP inhibitors in patients with other inactivated homologous recombination repair genes remains unclear. This knowledge gap and discrepancies in EMA/FDA approvals highlight the need for better biomarkers.
Ilse A. C. Spiekman, Niven Mehra, Laurien J. Zeverijn, Birgit S. Geurts, Karlijn Verkerk, Soemeya F. Haj Mohammad, Vincent van der Noort, Paul Roepman, Wendy W. J. de Leng, Anne M. L. Jansen, Addy C. M. van de Luijtgaarden, Theo van Voorthuizen, Tineke E. Buffart, Hans Gelderblom, Emile E. Voest, Henk M. W. Verheul   +15 more
wiley   +1 more source

How labor market institutions influence the relationship between exchange rate regimes and economic growth. [PDF]

PLoS One
Kuokštis V, Asali M, Spurga SA.
europepmc   +1 more source

Verekitug, a Novel Antibody Antagonist to the TSLP Receptor in Adults with Asthma: A 32‐Week Randomized Phase 1b Multiple Ascending‐Dose Trial

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 782-790, March 2026.
Verekitug, a novel, high‐affinity, fully human monoclonal antibody targeting thymic stromal lymphopoietin receptor (TSLPR), is in development as a potential treatment for severe asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), and chronic obstructive pulmonary disease (COPD).
Dave Singh, Chaim M. Brickman, Peter Lloyd, Ashish Kalra, Subhabrata Biswas, Arkadeep Sinha, Alex Mulvanny, Sumathi Sivapalasingam, Oren M. Becker, Aaron Deykin   +9 more
wiley   +1 more source

Compartment‐guided assembly of large‐scale molecular models with Bentopy

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Molecular dynamics simulations of whole cells and organelles aim to transform cell biology by providing a molecular view into the crowded cellular environment. However, constructing suitable starting configurations remains a major bottleneck due to their size and complexity.
M. S. S. Westendorp, J. A. Stevens, C. M. Brown, A. C. Dommer, T. A. Wassenaar, B. M. H. Bruininks, S. J. Marrink   +6 more
wiley   +1 more source

Experimental investigation of bio-improved laterite for use as a subgrade material in road construction. [PDF]

PLoS One
Sani RO, Ogunro TV, Akinwumi II.
europepmc   +1 more source

Profiling and Characterization of Seed Storage Proteins From Borage (Borago officinalis L.) Pressed Cake as a Novel Plant‐Based Protein Source

Sustainable Food Proteins, Volume 4, Issue 1, March 2026.
Borage (Borago officinalis L.) pressed cake, a by‐product of oil extraction, was profiled and characterized to evaluate its potential as a sustainable, plant‐based protein source. Protein fractionation revealed glutelin‐like proteins as predominant, accompanied by 2S albumin, 7S, and 11S globulin‐type proteins. Proteins exhibited high thermal stability
Suneru P. Perera, Rhea Thommana, Dierdre Culbert, Janiko Lindain, Thushan S. Withana‐Gamage   +4 more
wiley   +1 more source

Bipartite chromatin recognition by Hop1 from two diverged Holozoa. [PDF]

Life Sci Alliance
Rodriguez AA, Cirulli AE, Chau K, Nguyen J, Ye Q, Corbett KD.   +5 more
europepmc   +1 more source

Blockchain and Digital Technologies in the Telecommunications Industry

Thunderbird International Business Review, Volume 68, Issue 2, Page 139-163, March/April 2026.
ABSTRACT This article examines how fourth industrial revolution (4IR) technologies, specifically blockchain and digital twin technologies, can be utilized to address the energy supply challenge and enhance the management of distributed telecom infrastructure assets in a research context.
Charles Okeyia, Nuno Marques de Almeida, Joe Amad‐Echendu, Simplice A. Asongu   +3 more
wiley   +1 more source