Results 171 to 180 of about 106,175 (246)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Cystathionine beta-synthase promotes anoikis resistance and transcoelomic metastasis in ovarian cancer via SP1- ITGB1 regulation. [PDF]

Exp Hematol Oncol
Shaw P, Dey Bhowmik A, Jaswal AP, Velayutham R, Chiliveru S, Ricketts S, Xu C, Dhanasekaran DN, Zhao ZJ, Bhattacharya R, Mukherjee P, Dwivedi SKD, Rao G.   +12 more
europepmc   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

Factors Associated With Viral Load Suppression Among Adolescents and Young Adults Living With HIV on ART in Rwanda: Data From Rwanda HIV Case-Based Surveillance, 2019-2025. [PDF]

J Trop Med
Rwibasira GN, Kwizera JC, Karera S, Dzinamarira T, Holmes C, Ahmed A, Tuyishime A, Remera E, Paris DH, Glass TR.   +9 more
europepmc   +1 more source

Genetic Engineering of Tumor‐Infiltrating Lymphocytes (TIL) via a T‐Editor Platform to Enhance Anti‐Tumor Activity

Cancer Science, EarlyView.
A rapid and efficient CRISPR‐mediated gene editing platform for TIL engineering identified FAM84B as a novel potential target to enhance antitumor activity and pioneered the use of CBE to generate FAM84B loss‐of‐function TIL with enhanced antitumor activity.
Fenge Li, Xuejiao Ma, Yongming Xue, Jilong Yang, Ruijing Wang, Xiang Li, Chao Zhang, Wenhan Lu, Mei Liu, Yue Xu, Xinyi Wang, Shengnan Wu, Ning Kang, Chunhua Ma   +13 more
wiley   +1 more source

How Do LLMs See Charts? A Comparative Study on High‐Level Visualization Comprehension in Humans and LLMs

Computer Graphics Forum, EarlyView.
Abstract Designers often create visualizations to achieve specific high‐level analytical or communication goals. These goals require people to extract complex and interconnected data patterns. Prior perceptual studies of visualization effectiveness have focused on low‐level tasks, such as estimating statistical quantities, and have recently explored ...
Hyotaek Jeon, Hyunwook Lee, Minjeong Shin, Tapendra Pandey, Joohee Kim, Shinwook Seon, Daeun Jeong, Sungahn Ko, Ghulam Jilani Quadri   +8 more
wiley   +1 more source

Three new <i>Penicillium</i> species (section <i>Lanata-Divaricata</i>, <i>Aspergillaceae</i>, <i>Eurotiales</i>) from agricultural soil in Yunnan, China. [PDF]

MycoKeys
Zhang X, Shi S, Duan Z, Lai W, Yu Z.
europepmc   +1 more source

It Is Because of Our Society, but Inside the Child: Ambiguity in Dutch Youth Health Care Professionals' Understanding of Normalisation

Children &Society, EarlyView.
ABSTRACT In response to the rising number of children in youth care in the Netherlands, the Dutch Youth Act calls for normalisation, de‐medicalisation and unburdening. The present study investigated the views of physicians and nurses working in youth healthcare on the concept of normalisation.
Eva L. van Dijk, Sanne te Meerman, Ernst D. Thoutenhoofd, Albert W. Wienen, Donald G. van Tol, Tessa Overmars‐Marx, Els Evenboer, Laura Batstra   +7 more
wiley   +1 more source

Distinct and shared multimodal neuroimaging patterns in clinical frontotemporal dementia syndromes. [PDF]

Brain Commun
Sintini I, Singh-Reilly N, Ali F, Duffy JR, Clark HM, Utianski RL, Meade GF, Machulda MM, Satoh R, Dickson DW, Lowe VJ, Josephs KA, Whitwell JL.   +12 more
europepmc   +1 more source