Results 1 to 10 of about 685 (119)

The Role of Estradiol in Oxidative Stress in Health and Cystathionine ß-Synthase Deficiency: A Mechanistic Model. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Oxidative stress occurs when there is an imbalance between oxidants and antioxidants, leading to the accumulation of reactive oxygen species (ROS). Excessive ROS can damage lipids, proteins, and DNA, contributing to cellular dysfunction and disease.
Cruikshank A, Nijhout HF, Reed MC.
europepmc   +2 more sources

A model for developing dependable systems using a component‐based software development approach (MDDS‐CBSD)

IET Software, 2023
Component‐based software development (CBSD) is an emerging technology that integrates existing software components to swiftly develop and deploy big and complex software systems with little engineering effort, money, and time.
Hasan Kahtan, Ahmad Salah Al-Ahmad, Yehia Ibrahim Alzoubi   +2 more
exaly   +2 more sources

Effectiveness of Closed Blood-Sampling Devices in Critically Ill Adults: A Feasibility Trial. [PDF]

Nurs Crit Care
ABSTRACT Background Anaemia in critically ill patients is often worsened by diagnostic blood sampling. Closed blood sampling devices (CBSDs) may reduce iatrogenic blood loss and transfusion needs. However, robust evidence of their effectiveness and feasibility in the intensive care unit (ICU) setting is lacking.
Raurell-Torredà M, Arias-Rivera S, Fernández-Castillo RJ, Frade-Mera MJ, González-Caro MD, Zaragoza-García I, Andreu-Vázquez C, Muriel-García A, Grupo Ahorro‐Sangre (Blood‐Sparing Research Group).   +8 more
europepmc   +2 more sources

Targeting dCas9-SunTag to a Susceptibility Gene Promoter Is Sufficient for CRISPR Interference. [PDF]

Plant Direct
ABSTRACT Cassava production in sub‐Saharan Africa is severely impacted by diseases. Most pathogens require interaction with host susceptibility factors to complete their life cycles and cause disease. Targeted DNA methylation is an epigenetic strategy to alter gene expression in plants, and we previously reported that a zinc‐finger fused to DMS3 could ...
Lin ZD, Hernandez GL, Stanton MK, Zheng X, Gilbert KB, Veley KM, Jensen G, Yoder M, Feng S, Ghoshal B, Gardiner J, Wang M, Jacobsen SE, Carrington JC, Bart RS.   +14 more
europepmc   +2 more sources

Perception of dementia risk among Black adults: an ecological analysis of causal loop diagrams with a structural and social determinant of health composite index. [PDF]

Alzheimers Dement (N Y)
Abstract INTRODUCTION To investigate drivers of dementia risk disparities among older Black Americans using a community‐based system dynamics (CBSD) approach. METHODS Over 18 months, 234 participants created 36 causal loop diagrams (CLDs) on dementia risk.
Trani JF, Singh RK, Walker AI, Bekena S, Zhu Y, Babulal GM, Hart R.   +6 more
europepmc   +2 more sources

Leveraging Community-Based System Dynamics to Understand Long Covid Disparities in African American Communities: A Model for Health Equity Research. [PDF]

Health Expect
ABSTRACT Background Long Covid disproportionately affects African American communities, exacerbating pre‐existing health disparities and systemic barriers to care. Conventional public health interventions often fail to address the complex systemic issues at play due to a lack of grounding in community‐certified knowledge about the broader societal ...
Evans CR, Echols MR, Martin D, Taylor HA, Washington JA, Gbinigie O, Gaglioti AH, Wright W, Hovmand P.   +8 more
europepmc   +2 more sources

Exploring differences between women and men in treatment-seeking patients with compulsive buying-shopping disorder [PDF]

Scientific Reports
Compulsive buying-shopping disorder (CBSD) is associated with emotional distress, reduced daily functioning, and frequent comorbid mental health conditions.
Bjarn-Ove Tetzlaff, Tanja Bogel, Tobias A. Thomas, Nora M. Laskowski, Astrid Müller   +4 more
doaj   +2 more sources

Psychotherapy research for compulsive buying-shopping disorder: Quo vadis? [PDF]

Addictive Behaviors Reports
Aim The aim of this position paper is to address the question of how psychotherapy research for compulsive buying-shopping disorder (CBSD) should develop further.
Astrid Müller, Patrick Trotzke, Patricia Schaar, Tobias A. Thomas, Ekaterini Georgiadou, Sabine Steins-Loeber   +5 more
doaj   +2 more sources

Using community-based system dynamics to understand connections between housing and education: A case study with implications for homelessness prevention school-housing partnership. [PDF]

Am J Community Psychol
Abstract In some communities, schools and housing agencies are innovatively partnering to prevent family homelessness and protect students from the negative outcomes associated with housing hardship. While there is increasing interest in expanding the array of housing solutions via school‐housing partnership, more research is needed to understand the ...
Johnson JKM, Werner K, Bartley S, Dickenson E, Woodsby A, Tine ER, Yadama GN.   +6 more
europepmc   +2 more sources

Oxidative damage and mitochondrial dysfunction in cystathionine beta-synthase deficiency [PDF]

Scientific Reports
Cystathionine beta-synthase deficiency (CBSD) is the most prevalent inherited disorder of homocysteine metabolism in the transsulphuration pathway. Research have suggested oxidative stress and inflammation as candidate pathogenic mechanisms in CBSD. This
Mehmet Cihan Balci, Asuman Gedikbasi, Sukru Anil Dogan, Sevde Kahraman, Suzin Tatoryan, Sebnem Tekin Neijmann, Meryem Karaca, Fatmahan Atalar, Gulden Gokcay   +8 more
doaj   +2 more sources