Results 11 to 20 of about 56,789 (216)

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Talk to Your Data: An Agentic Artificial Intelligence‐Driven Decision‐Support Framework for Prosumer Energy Optimization and Recommendations

Advanced Intelligent Systems, EarlyView.
An agentic AI‐driven decision‐support framework for prosumers is proposed, integrating PV generation, load profiling, and multihorizon optimization within a four‐agent architecture. The approach significantly reduces grid dependence, enhances self‐sufficiency and prevents system oversizing.
Adela BÂRA, Simona‐Vasilica OPREA
wiley   +1 more source

Age‐associated B cells contribute to inflammation via antibody‐independent mechanisms in Takayasu's arteritis

Arthritis &Rheumatology, Accepted Article.
Objective Although Takayasu's arteritis (TAK) is not a prototypical autoantibody‐mediated disease, accumulating evidence suggests that B cells are involved. This study aimed to investigate the pathway of B‐cell activation and its contributions to TAK pathogenesis.
Chenglong Fang, Xiaoxi Yang, Xiaochuan Sun, Shangyi Jin, Lihong Du, Jinwei Gao, Jing Li, Zhen Chen, Yuexin Chen, Mengtao Li, Xinping Tian   +10 more
wiley   +1 more source

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source

Exploring the early observations of parents supporting their children with school attendance problems (SAPs): A co‐produced study

British Educational Research Journal, EarlyView.
Abstract School Attendance Problems (SAPs) represent a significant challenge requiring early identification and intervention. Current service provision often does not recognise early indicators that parents observe, creating gaps between when initial concerns are raised and formal support is provided.
Tereza Aidonopoulou‐Read, Michelle Pyer, Beth Bodycote, Jackie Campbell, Kirsteen Pyer   +4 more
wiley   +1 more source

The Association Between Perpetration of Relational Aggressive Tendencies and Adolescent Antisocial Behavior

Behavioral Sciences &the Law, EarlyView.
ABSTRACT Most research on relational aggression has primarily examined these behaviors among children, with limited exploration of its developmental progression during early adolescence and its associations with antisocial behaviors such as alcohol use, physical aggression, and rule‐breaking conduct.
Briana Amador, Timothy Lawrence, Qiyue Zhang, Ariel McField, Lily Palmer, Oi‐Man Kwok   +5 more
wiley   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Characterization of the Immune Response after Oral Cholera Vaccination (OCV) and Effects of Mycophenolate Mofetil on Priming of this Immune Response—A Randomized, Placebo‐Controlled Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Mycophenolate mofetil (MMF) is an immunosuppressive drug widely used by solid organ transplant recipients. Although it is known that MMF suppresses immune responses, its exact effects on specific vaccinations have not been investigated yet. Mucosal vaccinations are increasingly used, such as a cholera vaccination consisting of two oral immunizations ...
Boukje C. Eveleens Maarse, Aliede E. in 't Veld, Hendrika W. Grievink, Manon A.A. Jansen, Matthijs Moerland   +4 more
wiley   +1 more source

Psychological Treatment for Pediatric Feeding Disorder (PFD) and Avoidant/Restrictive Food Intake Disorder (ARFID)

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective To produce a consensus statement on the psychological treatment of feeding/eating aversions seen in pediatric feeding disorder (PFD) and avoidant/restrictive food intake disorder (ARFID), diagnoses that share common symptoms and psychological mechanisms but have historically been addressed separately in the literature. Method To help
Colleen T. Lukens, Robert M. Dempster, Kamryn T. Eddy, Hayley Estrem, Jessie E. Menzel, Richard J. Noel, Jaclyn L. Pederson, Ana L. Ramirez, Cuyler Romeo, William G. Sharp, Jennifer J. Thomas, Nancy L. Zucker, Hana F. Zickgraf   +12 more
wiley   +1 more source

Strategic Priorities for Advancing Eating Disorder Risk Reduction: A Narrative Review

International Journal of Eating Disorders, EarlyView.
ABSTRACT Despite decades of advances in treatment, eating disorders continue to impose substantial individual and societal burden, underscoring the need for earlier and more effective risk reduction. Prevention research has expanded considerably, producing a wide range of approaches that target modifiable risk factors, build individual coping skills ...
Hannah K. Jarman
wiley   +1 more source