Results 21 to 30 of about 429,331 (172)

I]CC1: A PARP-Targeting, Auger Electron–Emitting Radiopharmaceutical for Radionuclide Therapy of Cancer [PDF]

, 2023
Poly(adenosine diphosphate ribose) polymerase (PARP) has emerged as an effective therapeutic strategy against cancer that targets the DNA damage repair enzyme.
Veal, Mathew, Chan, CY, Chen, Z, Wilson, TC, Bart Cornelissen, Mosley, Michael, Guibbal, Florian, Zijun Chen, O'Neill, E, Cornelissen, B, Chan, Chung Ying, Thomas C. Wilson, Gouverneur, V, Chung Ying Chan, Mosley, M, Dias, Gemma, Véronique Gouverneur, Destro, Gianluca, Veal, M, Doreen Lau, Michael Mosley, Destro, G, Edward O’Neill, Wilson, Thomas C, Guibbal, F, Mathew Veal, Lau, D, Lau, Doreen, Cornelissen, Bart; id_orcid, Florian Guibbal, O'Neill, Edward, Chen, Zijun, Gouverneur, Véronique, Gemma Dias, Dias, G, Gianluca Destro   +35 more
core   +1 more source

Increasing the bulk of the 1TEL–target linker and retaining the 10×His tag in a 1TEL–CMG2‐vWa construct improves crystal order and diffraction limits

Acta Crystallographica Section D, Volume 79, Issue 10, Page 925-943, October 2023., 2023
Using a 1TEL–CMG2‐vWa construct, evidence is provided to support limiting the flexibility of linkers between TELSAM and proteins of interest and considering retaining polyhistidine purification tags in TELSAM‐fusion constructs. The phenomenon of TELSAM‐polymer flipping is also identified and a correction strategy is developed.TELSAM‐fusion ...
Parag L. Gajjar, Maria J. Pedroza Romo, Celeste M. Litchfield, Miles Callahan, Nathan Redd, Supeshala Nawarathnage, Sara Soleimani, Jacob Averett, Elijah Wilson, Andrew Lewis, Cameron Stewart, Yi-Jie Tseng, Tzanko Doukov, Andrey Lebedev, James D. Moody   +14 more
wiley   +1 more source

Crystal structures of 40- and 71-substitution variants of hydroxynitrile lyase from rubber tree. [PDF]

Acta Crystallogr D Struct Biol
Variants HNL16, HNL40 and HNL71 of hydroxynitrile lyase from Hevea brasiliensis contain 16, 40 and 71 mutations, respectively, to make increasingly larger regions surrounding the active site identical in sequence to the esterase SABP2. X‐ray structures of HNL40 and HNL71 reveal changes to the oxyanion hole and a new tunnel, which may contribute to ...
Pierce CT, Tan P, Greenberg LR, Walsh ME, Shi K, Nguyen AH, Meixner EL, Sarak S, Aihara H, Evans RL, Kazlauskas RJ.   +10 more
europepmc   +2 more sources

Comparison of Mycobacterium tuberculosis drug susceptibility using solid and liquid culture in Nigeria. [PDF]

, 2013
BACKGROUND: This study compares Mycobacterium tuberculosis culture isolation and drug sensitivity testing (DST) using solid (LJ) and liquid (BACTEC-MGIT-960) media in Nigeria.
Luis E Cuevas, Abdurrahman, Saddiq T, Yassin, Mohammed A, Sogaolu, Olumide M., Saddiq T Abdurrahman, Juliana O Lawson, Yassin, Mohammed A., Uzoewulu, Gertrude N, Juliana N Ebisike, Nanmdi Emenyonu, Lawson, Lovett, Mohammed A Yassin, Abdurrahman, Saddiq T., Uzoewulu, Gertrude N., Parry, Christopher M, Gertrude N Uzoewulu, Lawson, Juliana O., Lawson, Juliana O, Cuevas, Luis E, Ebisike, Juliana N., Christopher M Parry, Emenyonu, Nanmdi, Parry, Christopher, Olumide M Sogaolu, Sogaolu, Olumide M, Ebisike, Juliana N, Lovett Lawson, Cuevas, Luis   +27 more
core   +1 more source

Peer review of the pesticide risk assessment of the active substance clomazone. [PDF]

EFSA J
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Denmark, and co‐rapporteur Member State, Germany, for the pesticide active substance clomazone are reported.
European Food Safety Authority (EFSA), Álvarez F, Arena M, Auteri D, Leite SB, Binaglia M, Castoldi AF, Chiusolo A, Colagiorgi A, Colas M, Crivellente F, De Lentdecker C, De Magistris I, Egsmose M, Fait G, Ferilli F, Broussarad MF, Santonja GG, Gouliarmou V, Halling K, Ippolito A, Istace F, Jarrah S, Kardassi D, Kienzler A, Lanzoni A, Lava R, Leuschner R, Linguadoca A, Louisse J, Lythgo C, Magrans O, Mangas I, Mioč A, Miron I, Molnar T, Padovani L, Padricello V, Panzarea M, Parra Morte JM, Piti A, Rizzuto S, Rortais A, Santos M, Serafimova R, Sharp R, Szentes C, Terron A, Theobald A, Tiramani M, Vianello G, Villamar-Bouza L.   +51 more
europepmc   +2 more sources

Emergence and global spread of Listeria monocytogenes main clinical clonal complex [PDF]

, 2021
The bacterial foodborne pathogen Listeria monocytogenes clonal complex 1 (Lm-CC1) is the most prevalent clonal group associated with human listeriosis and is strongly associated with cattle and dairy products.
Listeria CC1 Study Group, IRAS OH Epidemiology Microbial Agents   +1 more
core  

A novel multidrug-resistant PVL-negative CC1-MRSA-1 IV clone emerging in Ireland and Germany likely originated in South-Eastern Europe [PDF]

, 2019
This study investigated the recent emergence of multidrug-resistant Panton-Valentine leukocidin (PVL)-negative CC1-MRSA-IV in Ireland and Germany. Ten CC1-MSSA and 139 CC1-MRSA isolates recovered in Ireland between 2004 and 2017 were investigated. These
Shore, Anna C., Schneider-Brachert, Wulf, Ehricht, Ralf, Earls, Megan R., Coleman, David C., Slickers, Peter, Simbeck, Alexandra, Vremerǎ, Teodora, Monecke, Stefan, Shore, Anna, Brennan, Gráinne I., Coleman, David, Dorneanu, Olivia S., Earls, Megan R, Brennan, Gráinne I, Shore, Anna C, Coleman, David C, Dorneanu, Olivia S   +17 more
core   +1 more source

Time course of transglycosylation by Endo-CC1^N180Q and Endo-CC1^N180H.

, 2015
Time course of transglycosylation of deglycosyalted RNase B by either End-CC1N180Q or Endo-CC1N180H was examined using different amount of complex type oligosaccharide derived from SGP. (A) Endo-CC1N180Q and 62.5 μg SGP. (B) Endo-CC1N180Q and 250 μg SGP.
Yujiro Higuchi (773330), Yasunari Eshima (773329), Takashi Kinoshita (440727), Shin-ichi Nakakita (595194), Kaoru Takegawa (14399)   +4 more
core   +1 more source

CC1 and CC3 for an example speaker.

, 2022
The CC time series for the speech envelope are shown in blue, and the CCs for the facial landmarks are shown in orange. Vertical lines indicate word onsets.
Nicolai F. Pedersen (13119042), Torsten Dau (559769), Lars Kai Hansen (13119045), Jens Hjortkjær (5601359)   +3 more
core   +1 more source

The crystal structure of Shethna protein II (FeSII) from Azotobacter vinelandii suggests a domain swap. [PDF]

Acta Crystallogr D Struct Biol
The Azotobacter vinelandii FeSII protein forms an oxygen‐resistant complex with the nitrogenase MoFe and Fe proteins.The Azotobacter vinelandii FeSII protein forms an oxygen‐resistant complex with the nitrogenase MoFe and Fe proteins. FeSII is an adrenodoxin‐type ferredoxin that forms a dimer in solution.
Kabasakal BV, McFarlane CR, Cotton CAR, Schmidt A, Kung A, Lieber L, Murray JW.   +6 more
europepmc   +2 more sources